Original paper
Characterization and Pharmacological Inhibition of the Pore-Forming Clostridioides difficile CDTb Toxin
Abstract
The clinically highly relevant Clostridioides (C.) difficile releases several AB-type toxins that cause diseases such as diarrhea and pseudomembranous colitis. In addition to the main virulence factors Rho/Ras-glycosylating toxins TcdA and TcdB, hypervirulent strains produce the binary AB-type toxin CDT. CDT consists of two separate proteins. The binding/translocation B-component CDTb facilitates uptake and translocation of the enzyme...
Paper Details
Title
Characterization and Pharmacological Inhibition of the Pore-Forming Clostridioides difficile CDTb Toxin
Published Date
May 28, 2021
Journal
Volume
13
Issue
6
Pages
390 - 390
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Notes
History