Identification (biology)

Internal medicine

Pathology

Glomerulosclerosis

Disease

Fibrosis

Biology

Matrix (chemical analysis)

Extracellular matrix

Chemistry

Proteinuria

Kidney

Kidney disease

Botany

Cell biology

Chromatography

Medicine

Ultrastructure

Journal of the American Society of Nephrology

Accumulation of extracellular matrix in organs and tissues is a feature of both aging and disease. In the kidney, glomerulosclerosis and tubulointerstitial fibrosis accompany the decline in function, which current therapies cannot address, leading to organ failure. Although histologic and ultrastructural patterns of excess matrix form the basis of human disease classifications, a comprehensive molecular resolution of abnormal matrix is lacking.

Identification of an Altered Matrix Signature in Kidney Aging and Disease