The Influence of Polysaccharides-Based Material on Macrophage Phenotypes

Published on May 10, 2021in Macromolecular Bioscience3.416
· DOI :10.1002/MABI.202100031
Zhuqing Li2
Estimated H-index: 2
(Iowa State University),
Kaitlin M. Bratlie22
Estimated H-index: 22
(Iowa State University)
Macrophage polarization is a key factor in determining the success of implanted tissue engineering scaffolds. Polysaccharides (derived from plants, animals, and microorganisms) are known to modulate macrophage phenotypes by recognizing cell membrane receptors. Numerous studies have developed polysaccharide-based materials into functional biomaterial substrates for tissue regeneration and pharmaceutical application due to their immunostimulatory activities and anti-inflammatory response. They are used as hydrogel substrates, surface coatings, and drug delivery carriers. In addition to their innate immunological functions, the newly endowed physical and chemical properties, including substrate modulus, pore size/porosity, surface binding chemistry, and the mole ratio of polysaccharides in hybrid materials may regulate macrophage phenotypes more precisely. Growing evidence indicates that the sulfation pattern of glycosaminoglycans and proteoglycans expressed on polarized macrophages leads to the changes in protein binding, which may alter macrophage phenotype and influence the immune response. A comprehensive understanding of how different types of polysaccharide-based materials alter macrophage phenotypic changes can be beneficial to predict transplantation/implantation outcomes. This review focuses on recent advances in promoting wound healing and balancing macrophage phenotypes using polysaccharide-based substrates/coatings and new directions to address the limitations in the current understanding of macrophage responses to polysaccharides.
#1Majid Salehi (Shahroud University of Medical Sciences)H-Index: 19
#2Arian Ehterami (IAU: Islamic Azad University)H-Index: 13
Last. Somayeh Ebrahimi-Barough (Tehran University of Medical Sciences)H-Index: 23
view all 5 authors...
Wounds have always been considered as one of the most common physical damages. Therefore, various researches have been conducted to find an appropriate method to improve wound healing process. Among various materials, since hydrogels have appropriate properties for wound healing, they are widely used for this purpose. In this study, to develop a potential wound dressing, different concentrations of naringenin (0%, 1%, 10% and 20%) were incorporated in alginate hydrogel followed by evaluating its...
8 CitationsSource
#1Ling Zhu (JNU: Jinan University)H-Index: 4
#2Shitian Chen (JNU: Jinan University)H-Index: 4
Last. Binghong Luo (JNU: Jinan University)H-Index: 17
view all 8 authors...
Abstract We present here a porous poly (L-lactide)/chitosan (PLLA/CS) composite scaffold with micro/nano-fiber hierarchical structure that was innovatively fabricated by combining 3D printing and thermally induced phase separation technology. Moreover, bioactive quercetin (Qu) was chosen to further functionalize the PLLA/CS scaffold with polydopamine (PDA) layer. The final results showed that the hydrophilicity and mechanical properties of the resulting PLLA/CS-D/Qu scaffold were obviously super...
13 CitationsSource
#1Aysegul Dede Eren (TU/e: Eindhoven University of Technology)H-Index: 3
#2Ravi Sinha (UM: Maastricht University)H-Index: 6
Last. Jan de Boer (TU/e: Eindhoven University of Technology)H-Index: 60
view all 9 authors...
Abstract Decellularized tissues and organs from animal sources are widely used in regenerative medicine and tissue engineering. However, in tendon tissue engineering there is not the only limitation in terms of tissue source -allografts and autografts- but also standardization of decellularization techniques. The goal of this study is to decellularize porcine Achilles tendon to be used as an off-the-shelf product for tendon reconstruction. We describe a novel, mild decellularization strategy whi...
2 CitationsSource
#1Sandrine Gulberti (University of Lorraine)H-Index: 13
#2Xianqing MaoH-Index: 11
Last. Sylvie Fournel-Gigleux (University of Lorraine)H-Index: 27
view all 4 authors...
Abstract Heparan-sulfate modifications are master regulators of the cross-talk between cell and matrix and modulate the biological activity of an array of HS binding proteins, including growth factors and chemokines, morphogens and immunity cell receptors. This review will highlight the importance of HS maturation mediated by N-deactetylase/sulfotransferases, 2- and 6O-sulfotransferases in cancer biology, and will focus on the 3O-sulfotransferases and on the terminal, rare 3O-sulfation, and thei...
5 CitationsSource
#1Yuan Yin (Fourth Military Medical University)H-Index: 13
#2Xiao-Tao He (Fourth Military Medical University)H-Index: 12
Last. Fa-Ming Chen (Fourth Military Medical University)H-Index: 30
view all 8 authors...
Abstract Increasing evidence indicates that material pore size can affect both macrophage (Mφ) polarization and new vessel formation within the compartment of a transplant. Using genipin cross-linked collagen/chitosan (Col-Ch) scaffolds with average pore sizes of 160 and 360 μm (Col-Ch-160 and Col-Ch-360, respectively) as material vascularization models, this study examined the influence of pore size-mediated M1-to-M2 transition of Mφs penetrating the scaffold on subsequent angiogenesis and vasc...
7 CitationsSource
#1Giulia Torrieri (UH: University of Helsinki)H-Index: 5
#2Flavia Fontana (UH: University of Helsinki)H-Index: 17
Last. Hélder A. SantosH-Index: 149
view all 15 authors...
The advent of nanomedicine has recently started to innovate the treatment of cardiovascular diseases, in particular myocardial infarction. Although current approaches are very promising, there is still an urgent need for advanced targeting strategies. In this work, the exploitation of macrophage recruitment is proposed as a novel and synergistic approach to improve the addressability of the infarcted myocardium achieved by current peptide-based heart targeting strategies. For this purpose, an ac...
11 CitationsSource
#1Erika J. Gruber (Cornell University)H-Index: 5
#2Cynthia A. Leifer (Cornell University)H-Index: 28
Immune cells continuously patrol the body to rapidly detect and respond to endogenous and exogenous insults. Compared with other cell types, immune cells are extremely motile, able to undergo dramatic morphological changes during tissue transit, and capable of dynamic cell–cell interactions for Ag presentation and transmigration under static and circulatory flow conditions. A direct consequence of their motility is that immune cells encounter microenvironments that vary tremendously in terms of ...
7 CitationsSource
#1Hang Xue (HUST: Huazhong University of Science and Technology)H-Index: 8
#2Liangcong Hu (HUST: Huazhong University of Science and Technology)H-Index: 10
Last. Guohui Liu (HUST: Huazhong University of Science and Technology)H-Index: 15
view all 17 authors...
Abstract Hydrogels could be promising wound healing dressings that maintain a moist environment in the wound site and accelerate wound healing. However, the lack of antibacterial effect, suitable mechanical property and adhesiveness limits their applications. Here, we designed a quaternized chitosan-Matrigel-polyacrylamide (QCS-M-PAM) hydrogel with multi-functions. The morphology, swelling ratio, mechanical test, antimicrobial property, hemostatic performance and biocompatibility of the hybrid h...
35 CitationsSource
#1María Puertas-Bartolomé (ISCIII: Carlos III Health Institute)H-Index: 2
#2Lorena Benito-Garzón (University of Salamanca)H-Index: 4
Last. Julio San Román (ISCIII: Carlos III Health Institute)H-Index: 44
view all 6 authors...
Abstract Chronic wounds are particularly difficult to heal and constitute an important global health care problem. Some key factors that make chronic wounds challenging to heal are attributed to the incessant release of free radicals, which activate the inflammatory system and impair the repair of the wound. Intrinsic characteristics of hydrogels are beneficial for wound healing, but the effective control of free radical levels in the wound and subsequent inflammation is still a challenge. Catec...
13 CitationsSource
#1Qingsheng Liu (Cornell University)H-Index: 13
#2Alan Chiu (Cornell University)H-Index: 16
Last. Minglin Ma (Cornell University)H-Index: 40
view all 18 authors...
Foreign body reaction (FBR) to implanted biomaterials and medical devices is common and can compromise the function of implants or cause complications. For example, in cell encapsulation, cellular overgrowth (CO) and fibrosis around the cellular constructs can reduce the mass transfer of oxygen, nutrients and metabolic wastes, undermining cell function and leading to transplant failure. Therefore, materials that mitigate FBR or CO will have broad applications in biomedicine. Here we report a gro...
26 CitationsSource
Cited By0