Zhuqing Li
Iowa State University
Self-healing hydrogelsMethacrylateCell migrationFocal adhesionGlycosaminoglycanChemistryMyofibroblastMacrophage polarizationSwellingMacrophageWound healingFibroblastFibrosisGellan gumTransplantationTissue engineeringPolymerMyosinTissue cultureCell biology
4Publications
2H-index
27Citations
Publications 4
Newest
#1Zhuqing Li (Iowa State University)H-Index: 2
#2Kaitlin M. Bratlie (Iowa State University)H-Index: 22
Macrophage polarization is a key factor in determining the success of implanted tissue engineering scaffolds. Polysaccharides (derived from plants, animals, and microorganisms) are known to modulate macrophage phenotypes by recognizing cell membrane receptors. Numerous studies have developed polysaccharide-based materials into functional biomaterial substrates for tissue regeneration and pharmaceutical application due to their immunostimulatory activities and anti-inflammatory response. They are...
Source
#1Zhuqing Li (Iowa State University)H-Index: 2
#2Kaitlin M. Bratlie (Iowa State University)H-Index: 22
Abstract In tissue regeneration, the goal is to regenerate tissue similar to what was damaged or missing while preventing fibrotic scarring, which may lead to decreased mechanical strength and dissimilar tissue characteristics compared to native tissue. We believe collagen orientation plays a critical role in wound contraction and scarring and that it is modulated by myofibroblasts. We used macrophage conditioned medium to simulate complex events that can influence the fibroblast phenotype durin...
Source
#1Zhuqing Li (Iowa State University)H-Index: 2
#2Kaitlin M. Bratlie (Iowa State University)H-Index: 22
In tissue engineering scaffolds, macrophages play a critical role in determining the host response to implanted biomaterials. Macrophage phenotype is dynamic throughout the host response, and a balance of phenotypes is essential for timely progression from injury to proper wound healing. Therefore, it is important to predict how materials will modulate the response of macrophages. In this study, we investigated the effect of methacrylated gellan gum (GG) hydrogels on macrophage phenotype and pro...
1 CitationsSource
#1Zihao Xu (Iowa State University)H-Index: 4
#2Zhuqing Li (Iowa State University)H-Index: 2
Last. Kaitlin M. Bratlie (Iowa State University)H-Index: 22
view all 4 authors...
Gellan gum is a naturally occurring polymer that can cross-link in the presence of divalent cations to form biocompatible hydrogels. However, physically cross-linked gellan gum hydrogels lose their stability under physiological conditions, thus restricting the applications of these hydrogels in vivo. To improve the mechanical strength of the gels, we incorporated methacrylate into the gellan gum and chemically cross-linked the hydrogel through three polymerization methods: step growth through th...
15 CitationsSource