Macromolecular Bioscience
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#1Chiara Pretto (TU/e: Eindhoven University of Technology)H-Index: 1
#2Miao Tang ('QUB': Queen's University Belfast)H-Index: 3
Last. Jan C. M. van Hest (TU/e: Eindhoven University of Technology)H-Index: 75
view all 7 authors...
Due to its small size, easy accessibility and immune privileged environment, the eye represents an ideal target for therapeutic nucleic acids in the treatment of posterior segment ocular diseases, such as age-related macular degeneration (AMD). Among nanocarriers that can be used to achieve nucleic acid delivery, virus-like particles (VLPs) obtained from the Cowpea chlorotic mottle virus (CCMV) are an appealing platform, because of their loading capacity, ease of manufacture and amenability for ...
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#1Yu Zhang (CAS: Chinese Academy of Sciences)H-Index: 57
#2Xinming Liu (CAS: Chinese Academy of Sciences)H-Index: 27
Last. Xuesi Chen (CAS: Chinese Academy of Sciences)H-Index: 114
view all 7 authors...
Chemotherapy using vascular targeting agents is an emerging new approach for cancer therapy. Combretastatin A4 (CA4) is a leading vascular-disrupting agent that targets the tumor blood vasculature for clinical tumor elimination. However, the extremely poor water solubility of CA4 hinders its biomedical applications. In this study, nanoparticles composed of novel PEGylated alternating copolymer-CA4 conjugates are designed to improve the therapeutic efficiency of CA4. First, an alternating copolym...
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#1Elham Akbari (AUT: Amirkabir University of Technology)
#2Rana Imani (AUT: Amirkabir University of Technology)H-Index: 13
Last. Saeed Heidari Keshel (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 18
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Here, a novel ring-implanted poly vinyl alcohol (PVA) contact lens (CL) is fabricated and evaluated as a therapeutic CL with potential of sustained release of hyaluronic acid (HA). HA is loaded on chitosan (CS) nanoparticles (NPs) and then the HA-loaded NPs are dispersed in a ring shape PVA hydrogel which is implanted in the final PVA CL. Results show that HA is successfully loaded on NPs (520 ± 18 nm) with loading efficacy of 87% and loading capacity of 50%. The CL hydrogel has a 275% swelling ...
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#1Marina Rodrigues Tavares (CAS: Academy of Sciences of the Czech Republic)H-Index: 3
#2Michal Pechar (CAS: Academy of Sciences of the Czech Republic)H-Index: 23
Last. Tomáš Etrych (CAS: Academy of Sciences of the Czech Republic)H-Index: 40
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This paper summarizes the area of biomedicinal polymers, which serve as nanomedicines even though they do not contain any anticancer or antiinflammatory drugs. These polymer nanomedicines with unique design are in the literature highlighted as a novel class of therapeutics called "drug-free macromolecular therapeutics." Their therapeutic efficacy is based on the tailored multiple presentations of biologically active vectors, i.e., peptides, oligopeptides, or oligosaccharides. Thus, they enable, ...
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#1Matthias Röber (Humboldt University of Berlin)H-Index: 2
#2Thomas Scheibel (University of Bayreuth)H-Index: 63
Last. Hans G. Börner (Humboldt University of Berlin)H-Index: 57
view all 3 authors...
Collagen mimetic peptides (CMPs), which imitate various structural or functional features of natural collagen, constitute advanced models illuminating the folding aspects of the collagen triple helix (CTH) motif. In this study, the CMPs of repeating Gly-Pro-Pro (GPP) triplets are tethered to an organic scaffold based on a tris(2-aminoethyl) amine (TREN) derivative (TREN(sucOH)3 ). These three templated peptide strands are further expanded via native chemical ligation to increase the number of ...
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#1Zhenyu Jin (NU: Nanjing University)
#2Qingyu Zhao (NU: Nanjing University)
Last. Yong Hu (NU: Nanjing University)H-Index: 22
view all 5 authors...
Hypoxia as one of the most prominent features in tumors, has presented negative effects on tumor therapies including photodynamic therapy, radiotherapy, and chemotherapies, leading to the tumor regeneration and metastasis. Recently, nanomedicines have been proposed to handle the hypoxia dilemma. Some nanomedicines alleviated hypoxia to enhance the therapeutic effect, others used hypoxia-sensitive substances to treat tumor. Among them, macromolecular nanomaterials-based nanomedicine has attracted...
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#1Wenjing Zhang (WMU: Wenzhou Medical College)H-Index: 3
#2Suyan Shan (ZJU: Zhejiang University)
Last. Yong Liu (WMU: Wenzhou Medical College)H-Index: 33
view all 8 authors...
Antibiotic-resistant bacterial strains are a major cause of disease. They continue to remain a challenge in the clinic particularly in the vision system. For example, infectious endophthalmitis is a major blind-causing disease caused by bacteria. A highly efficient synergistic antibacterial treatment that uses a photothermal antibacterial therapeutic with a chemo-antibacterial therapeutic in a multifunctional nanocomposite is reported. It is prepared by immobilizing vancomycin onto the surface o...
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#1Cristina Mondelo-García (Group Health Research Institute)H-Index: 4
#2Enrique José Bandín-Vilar (Group Health Research Institute)H-Index: 2
Last. Francisco J. Otero-Espinar (University of Santiago de Compostela)H-Index: 24
view all 11 authors...
Vitreo-retinal disorders constitute a significant portion of treatable ocular diseases. These pathologies often require vitreo-retinal surgery and, as a consequence, the use of vitreous substitutes. Nowadays, the vitreous substitutes that are used in clinical practice are mainly divided into gases (air, SF6 , C2 F6 , C3 F8 ) and liquids (perfluorocarbon liquids, silicone oils, and heavy silicone oils). There are specific advantages and drawbacks to each of these, which determine their clinical i...
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#1Zhuqing Li (Iowa State University)H-Index: 2
#2Kaitlin M. Bratlie (Iowa State University)H-Index: 22
Macrophage polarization is a key factor in determining the success of implanted tissue engineering scaffolds. Polysaccharides (derived from plants, animals, and microorganisms) are known to modulate macrophage phenotypes by recognizing cell membrane receptors. Numerous studies have developed polysaccharide-based materials into functional biomaterial substrates for tissue regeneration and pharmaceutical application due to their immunostimulatory activities and anti-inflammatory response. They are...
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#1Ji-Hyeon Song (Konkuk University)H-Index: 6
#2Heesun Jung (Konkuk University)H-Index: 7
Last. Hyejung Mok (Konkuk University)H-Index: 32
view all 4 authors...
Here, as a proof of concept, hybrid vesicles (VEs) are developed from two types of cancer cells, MCF-7 and HeLa, for the dual targeting of the anticancer drug doxorubicin (Dox) to cancer cells via homotypic interactions. Hybrid VEs with a size of 181.8 ± 28.2 nm and surface charge of -27.8 ± 1.9 mV are successfully prepared by the fusion of MCF-7 and HeLa VEs, as demonstrated by the fluorescence resonance energy transfer assay. The hybrid VEs exhibit enhanced intracellular uptake both in MCF-7 a...
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Self-healing hydrogels
Organic chemistry
Chemistry
Polymer chemistry
Materials science
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