Internal medicine

Pathology

Clinical endpoint

Placebo

Denosumab

Bone mineral

Quantitative computed tomography

Urology

Cardiology

Bone remodeling

Randomized controlled trial

Alternative medicine

Osteoporosis

Stenosis

Medicine

Circulation

Valvular calcification is central to the pathogenesis and progression of aortic stenosis, with preclinical and observational studies suggesting that bone turnover and osteoblastic differentiation of valvular interstitial cells are important contributory mechanisms. We aimed to establish whether inhibition of these pathways with denosumab or alendronic acid could reduce disease progression in aortic stenosis.

Effect of Denosumab or Alendronic Acid on the Progression of Aortic Stenosis: A Double-Blind Randomized Controlled Trial