Impact of Breast Reconstruction on Biophysical Parameters of Mammary Skin in Patients Receiving Postmastectomy Radiotherapy for Breast Cancer

Published on Apr 1, 2021in Journal of Breast Cancer2.241
· DOI :10.4048/JBC.2021.24.E23
Haeyoung Kim10
Estimated H-index: 10
(SMC: Samsung Medical Center),
Danbee Kang15
Estimated H-index: 15
(SMC: Samsung Medical Center)
+ 7 AuthorsKyeong Tae Lee4
Estimated H-index: 4
(SMC: Samsung Medical Center)
PURPOSE In this study, we examined the impact of reconstruction using tissue expander insertion (TEI) on the risk of radiation dermatitis in patients undergoing postmastectomy radiotherapy (PMRT). METHODS Between August 2015 and March 2019, patients with breast cancer who had received systemic chemotherapy and PMRT were prospectively included. Skin parameters, including melanin, erythema, hydration, sebum, and elasticity, were measured using a multi-probe instrument at 6 time points: before the initiation of radiotherapy (pre-RT), at weeks 1, 3, and 5 during radiotherapy (weeks 1-5), and 1 and 3-month after radiotherapy (post-RT-1m and post-RT-3m). Patient-reported outcomes (PROs) were assessed at each time point. Changes in biophysical parameters and PRO were compared between patients with and without TEI (TEI+ vs. TEI-). RESULTS Thirty-eight patients, including 18 with TEI+ and 20 with TEI-, were analyzed. The pattern of time-course changes in biophysical parameters and PRO did not differ between TEI+ and TEI- patients. The melanin index was highest at post-RT-1m, while the erythema index was highest at week 5. At post-RT-3m, TEI+ patients presented higher melanin values than TEI- patients, with no statistical significance (coefficient, 47.9 vs. 14.2%; p = 0.07). In all patients, water content decreased throughout the measurement period. At post-RT-3m, TEI+ patients demonstrated a further decrease in water content, while the TEI- group nearly recovered the water content to pre-RT status (coefficient, -17.1, -2.5; p = 0.11). The sebum and elasticity levels were not altered by TEI. CONCLUSION In patients undergoing PMRT, TEI did not significantly affect the changing patterns of skin biophysical parameters and PRO during radiotherapy.
#1Ji-Hye Park (SMC: Samsung Medical Center)H-Index: 11
#2Hyun Jeong Byun (SMC: Samsung Medical Center)H-Index: 2
Last. Dongryul Oh (SMC: Samsung Medical Center)H-Index: 19
view all 7 authors...
Acute radiodermatitis is one of the major complications when radiation therapy (RT) is delivered to the head and neck region in cases of head and neck cancers or lung cancers with supraclavicular lymph node metastasis. In these cases, high dose of RT is generally used so that acute radiodermatitis is observed in more than 90% of patients, and it negatively affects patients’ quality of life. In this pilot study, we evaluated the clinical feasibility of photobiomodulation (PBM) therapy before cond...
8 CitationsSource
#1Sang Yull KangH-Index: 4
#2Yoo Seok Kim (Chosun University)H-Index: 5
Last. Hyun Jo YounH-Index: 21
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: This article describes the breast cancer statistics in Korea, including the incidence, type of surgical procedure, stage, and molecular subtype, using the Korean Breast Cancer Society (KBCS) and Korea Central Cancer Registry data. There were a total of 26,534 new breast cancer diagnoses in 2017 in Korea, of which 4,139 were carcinoma in situ cases and 22,395 were invasive cancer cases. The age standardized rate of breast cancer was 75.3 per 100,000 women in 2017 (63.0 of invasive carcinoma and...
32 CitationsSource
#1Marceila de Andrade Fuzissaki (UFU: Federal University of Uberlandia)H-Index: 2
Last. Yara Cristina de Paiva Maia (UFU: Federal University of Uberlandia)H-Index: 10
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Abstract Context In the oncology field, quality of life (QoL) is recognized as an essential component. However, few studies have evaluated radiotherapy (RT) and its adverse events, specifically radiodermatitis. Objectives The objective of this study was to investigate the influence of radiodermatitis severity on QoL of women with breast cancer (BC) throughout RT. Methods A prospective cohort study was conducted with 100 BC patients evaluated weekly during RT. The Dermatology Life Quality Index q...
10 CitationsSource
#1Mami Ogita (UTokyo: University of Tokyo)H-Index: 5
#2Kenji SekiguchiH-Index: 12
Last. Jiro KawamoriH-Index: 9
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Background We conducted a randomized trial to evaluate the efficacy of heparinoid moisturization for radiation dermatitis. We report the time-course of sebum content after whole breast radiotherapy (WBRT) and the efficacy of heparinoid moisturizer.
3 CitationsSource
#1Jae-Won Kim (Yeungnam University)H-Index: 3
#2Jun Ho Lee (Yeungnam University)H-Index: 11
Last. Kyu Jin Chung (Yeungnam University)H-Index: 10
view all 5 authors...
BACKGROUND: Previously, surveys have been used to investigate breast reconstruction statistics. Since 2015, breast reconstruction surgery after mastectomy has been covered by the National Health Insurance Service in Korea, and data from breast reconstruction patients are now available from the Health Insurance Review and Assessment Service (HIRA). We investigated statistics in breast reconstruction in Korea through statistics provided by the HIRA Big Data Hub. METHODS: We investigated the number...
8 CitationsSource
#1Kenji SekiguchiH-Index: 12
#2Keiko Akahane (Jichi Medical University)H-Index: 5
Last. Jiro KawamoriH-Index: 9
view all 9 authors...
Background: The application of heparinoid moisturizer for 2 weeks following whole-breast radiotherapy (WBRT) was previously reported to significantly increase skin water content (WC) and help improve skin dryness and desquamation. The prospective open-label, randomized trial included an exploratory arm to investigate the preventive efficacy of heparinoid moisturizer for acute radiation dermatitis (ARD). Methods: Between April 2011 and April 2013, patients receiving WBRT were assigned (1:2:2) to ...
5 CitationsSource
#1Elisa Bellini (University of Parma)H-Index: 4
#2Marianna PesceH-Index: 9
Last. Edoardo Raposio (University of Parma)H-Index: 26
view all 4 authors...
Objective. Breast cancer, the most common malignancy in women, comprises 18% of all female cancers. Mastectomy is an essential intervention to save lives, but it can destroy one’s body image, causing both physical and psychological trauma. Reconstruction is an important step in restoring patient quality of life after the mutilating treatment. Material and Methods. Tissue expanders and implants are now commonly used in breast reconstruction. Autologous reconstruction allows a better aesthetic res...
12 CitationsSource
#1Fatimah Haruna (Trinity College, Dublin)H-Index: 2
#2Andrea Lipsett (Trinity College, Dublin)H-Index: 2
Last. Laure Marignol (Trinity College, Dublin)H-Index: 18
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AIM: To evaluate the efficacy of topical corticosteroids in managing acute radiation dermatitis (RD) in female breast cancer patients. MATERIALS AND METHODS: MEDLINE, EMBASE, CINAHL, CENTRAL, ScienceDirect, Google Scholar and were searched up to and including March 2017 to identify Randomised Controlled Trials (RCTs) assessing topical corticosteroids for the management and prevention of acute RD. RESULTS: Ten RCTs (919 participants) were identified. Meta-analysis, including re...
38 CitationsSource
#1Jieun Lee (SMC: Samsung Medical Center)H-Index: 16
#2Won Soon Park (SMC: Samsung Medical Center)H-Index: 42
Last. Juhee Cho (SMC: Samsung Medical Center)H-Index: 1
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Purpose To find out which symptoms most frequently and severely affect breast cancer patients during radiotherapy and how patients manage the symptoms and unmet needs.
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#1Muhammad Abdur Razzak (UM: University of Malaya)H-Index: 1
#2Md. Sanower Hossain (UM: University of Malaya)H-Index: 4
Last. Mohammad Tariqur Rahman (UM: University of Malaya)H-Index: 14
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The increased use of tissue expander in the past decades and its potential market values in near future give enough reasons to sum up the consequences of tissue expansion. Furthermore, the patients have the right to know underlying mechanisms of adaptation of inserted biomimetic, its bioinspired materials and probable complications. The mechanical strains during tissue expansion are related to several biological phenomena. Tissue remodelling during the expansion is highly regulated and depends o...
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