Colonic epithelial adaptation to EGFR-independent growth induces chromosomal instability and is accelerated by prior injury
Abstract
Although much is known about the gene mutations required to drive colorectal cancer (CRC) initiation, the tissue-specific selective microenvironments in which neoplasia arises remains less characterized. Here, we determined whether modulation of intestinal stem cell niche morphogens alone can exert a neoplasia-relevant selective pressure on normal colonic epithelium. Using adult stem cell-derived murine colonic epithelial organoids (colonoids),...
Paper Details
Title
Colonic epithelial adaptation to EGFR-independent growth induces chromosomal instability and is accelerated by prior injury
Published Date
May 1, 2021
Journal
Volume
23
Issue
5
Pages
488 - 501
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Notes
History