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#1Afsar Ali Mian (Aga Khan University)H-Index: 1
#2Usva Zafar (Aga Khan University)H-Index: 1
Last. El-Nasir Lalani (Aga Khan University)H-Index: 36
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Tyrosine kinase inhibitors (TKIs) such as imatinib, nilotinib, dasatinib, and ponatinib have significantly improved the life expectancy of Philadelphia chromosome-positive (Ph+) acute lymphocytic leukemia (ALL) patients; however, resistance to TKIs remains a major clinical challenge. Point mutations in the tyrosine kinase domain (TKD) of BCR-ABL1 have emerged as the predominant cause of acquired resistance. In approximately 30% of patients, the mechanism of resistance to TKIs remains elusive. Th...
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#1Chinnadurai Mani (TTUHSC: Texas Tech University Health Sciences Center)H-Index: 1
#2Kaushlendra Tripathi (USA: University of South Alabama)H-Index: 12
Last. Komaraiah Palle (TTUHSC: Texas Tech University Health Sciences Center)H-Index: 1
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Ovarian cancer (OC) is one of the most lethal type of cancer in women due to a lack of effective targeted therapies and high rates of treatment resistance and disease recurrence. Recently Poly (ADP-ribose) polymerase inhibitors (PARPi) have shown promise as chemotherapeutic agents; however, their efficacy is limited to a small fraction of patients with BRCA mutations. Here we show a novel function for the Hedgehog (Hh) transcription factor Glioma associated protein 1 (GLI1) in regulation of key ...
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#1Jung Min Suh (Ewha Womans University)H-Index: 1
#2Yelin Son (Ewha Womans University)
Last. Yun Soo Bae (Ewha Womans University)H-Index: 38
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Previously we demonstrated that Ahnak mediates transforming growth factor-β (TGFβ)-induced epithelial-mesenchymal transition (EMT) during tumor metastasis. It is well-known that circulating tumor cells (CTCs) invade the vasculature of adjacent target tissues before working to adapt to the host environments. Currently, the molecular mechanism by which infiltrated tumor cells interact with host cells to survive within target tissue environments is far from clear. Here, we show that Ahnak regulates...
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#2Yu ChenH-Index: 5
Last. Rieko OhkiH-Index: 12
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Abstract null null Genomic analysis of Pancreatic Neuroendocrine Tumors (PanNETs) has revealed that these tumors often lack mutations in typical cancer-related genes such as the tumor suppressor gene p53. Instead, PanNET tumorigenesis usually involves mutations in specific PanNET-related genes, such as tumor suppressor gene MEN1. Using a PanNET mouse model, human tissues and human cell lines, we studied the cross-talk among MEN1, p53 and Notch signaling pathways and their role in PanNETs. Here, ...
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#1Hua Zhou (UMB: University of Maryland, Baltimore)H-Index: 10
#2Maricel G. Kann (UMBC: University of Maryland, Baltimore County)H-Index: 21
Last. John R. Basile (UMB: University of Maryland, Baltimore)H-Index: 22
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#1Brent Holmes (Veterans Health Administration)H-Index: 12
#2Angelica Benavides-Serrato (Veterans Health Administration)H-Index: 8
Last. Joseph Gera (UCLA: University of California, Los Angeles)H-Index: 28
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The Hippo and mTOR signaling cascades are major regulators of cell growth and division. Aberrant regulation of these pathways has been demonstrated to contribute to gliomagenesis and result in enhanced glioblastoma proliferation and invasive characteristics. Several crosstalk mechanisms have been described between these two pathways, although a complete picture of these signaling interactions is lacking and is required for effective therapeutic targeting. Here we report the ability of mTORC2 to ...
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#1Eri Munekage (Kōchi University)H-Index: 10
#2Satoshi Serada (Iwate Medical University)H-Index: 1
Last. Tsutomu Namikawa (Kōchi University)H-Index: 22
view all 14 authors...
An antibody-drug conjugate (ADC) is a promising therapeutic modality because selective and effective delivery of an anti-cancer drug is achieved by drug-conjugated antibody-targeting cancer antigen. Glypican 1 (GPC1) is highly expressed in malignant tumors, including pancreatic ductal adenocarcinoma (PDAC) and esophageal squamous cell carcinoma (ESCC). Herein, we describe the usefulness of GPC1-targeting ADC. Humanized anti-GPC1 antibody (clone T2) was developed and conjugated with monomethyl au...
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#1Gabriele Manzella (Boston Children's Hospital)H-Index: 3
#2Devmini C Moonamale (Boston Children's Hospital)
Last. Beat W. Schäfer (Boston Children's Hospital)H-Index: 71
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First-line therapy for most pediatric sarcoma is based on chemotherapy in combination with radiotherapy and surgery. A significant number of patients experience drug resistance and development of relapsed tumors. Drugs that have the potential to re-sensitize relapsed tumor cells toward chemotherapy treatment are therefore of great clinical interest. Here, we used a drug profiling platform with PDX-derived primary rhabdomyosarcoma cells to screen a large drug library for compounds re-sensitizing ...
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#1Yihui Ma (Zhengzhou University)H-Index: 6
#2Peiyi Xia (Zhengzhou University)
Last. Yanan Jiang (Zhengzhou University)
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Abstract null null Protein Disulfide Isomerase Family A Member 6 (PDIA6) is an endoplasmic reticulum protein that is capable of catalyzing protein folding and disulfide bond formation. Abnormally elevated expression of PDIA6 has been reported to predict poor outcomes in various cancers. Herein, gain-of- and loss-of-function experiments were performed to investigate how PDIA6 participated in the carcinogenesis of pancreatic cancer (PC). By analyzing the protein expression of PDIA6 in 28 paired PC...
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#1Emanuela Guerra (University of Chieti-Pescara)H-Index: 15
#2Marco Trerotola (University of Chieti-Pescara)H-Index: 21
Last. Antonino Moschella (UNIME: University of Messina)
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We recently reported that activation of Trop-2 through its cleavage at R87-T88 by ADAM10 underlies Trop-2-driven progression of colon cancer. However, the mechanism of action and pathological impact of Trop-2 in metastatic diffusion remain unexplored. Through searches for molecular determinants of cancer metastasis, we identified TROP2 as unique in its up-regulation across independent colon cancer metastasis models. Overexpression of wild-type Trop-2 in KM12SM human colon cancer cells increased ...
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