Neoplasia
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#1Bo-Ram Jin (Sangji University)H-Index: 6
#2Kyung-Sook Chung (Kyung Hee University)H-Index: 15
Last. Hyo-Jin An (Sangji University)H-Index: 22
view all 7 authors...
Previously, we found that rosmarinic acid (RA) exerted anti-inflammatory activities in a dextran sulfate sodium (DSS)-induced colitis model. Here, we investigated the anti-tumor effects of RA on colitis-associated colon cancer (CAC) and the underlying molecular mechanisms. We established an azoxymethane (AOM)/DSS-induced CAC murine model for in vivo studies and used a conditioned media (CM) culture system in vitro. H&E staining, immunohistochemistry, western blot assay, enzyme-linked immunosorbe...
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#1Runping Fang (NKU: Nankai University)H-Index: 10
#2Lihong Ye (NKU: Nankai University)H-Index: 48
Last. Hui Shi (Jining Medical University)
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Breast cancer is believed to be driven by epigenetic regulation of genes implicated in cell proliferation, survival, and differentiation. Recently, aberrant N6-methyladenosine (m6A) decorations turned up as crucial epigenetic regulator for malignant breast cancer, which may serve as new targets for breast cancer treatment. Here we briefly outline the functions of m6A and its regulatory proteins, including m6A "writers," "readers," and "erasers" on RNA life fate, recapitulate the latest breakthro...
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#2Alla ArzumanyanH-Index: 9
Last. Mark A. FeitelsonH-Index: 39
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Abstract Chronic infection with hepatitis B virus (HBV) is a major risk factor for the development of hepatocellular carcinoma (HCC). The HBV encoded oncoprotein, HBx, alters the expression of host genes and the activity of multiple signal transduction pathways that contribute to the pathogenesis of HCC by multiple mechanisms independent of HBV replication. However, it is not clear which pathways are the most relevant therapeutic targets in hepatocarcinogenesis. Short chain fatty acids (SCFAs) h...
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#1A Gaza (FAU: University of Erlangen-Nuremberg)H-Index: 1
#2V Fritz (FAU: University of Erlangen-Nuremberg)H-Index: 4
Last. Peter Dietrich (FAU: University of Erlangen-Nuremberg)H-Index: 12
view all 14 authors...
The poor prognosis of advanced hepatocellular carcinoma (HCC) is driven by diverse features including dysregulated microRNAs inducing drug resistance and stemness. Lin-28 homolog A (LIN28A) and its partner zinc finger CCHC-type containing 11 (ZCCHC11) cooperate in binding, oligouridylation and subsequent degradation of tumorsuppressive let-7 precursor microRNAs. Functionally, activation of LIN28A was recently shown to promote stemness and chemoresistance in HCC. However, the expression and regul...
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#1Annkathrin Koch (Goethe University Frankfurt)
#2Birte Jeiler (Goethe University Frankfurt)
Last. Simone Fulda (Goethe University Frankfurt)H-Index: 99
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Burkitt's lymphoma (BL) is a highly aggressive form of B-cell non-Hodgkin's lymphoma. The clinical outcome in children with BL has improved over the last years but the prognosis for adults is still poor, highlighting the need for novel treatment strategies. Here, we report that the combinational treatment with the Smac mimetic BV6 and TRAIL triggers necroptosis in BL when caspases are blocked by zVAD.fmk (TBZ treatment). The sensitivity of BL cells to TBZ correlates with MLKL expression. We demo...
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#1María Ovejero-Sánchez (University of Salamanca)H-Index: 1
#2Rogelio González-Sarmiento (University of Salamanca)H-Index: 34
Last. Ana B. Herrero (University of Salamanca)H-Index: 14
view all 3 authors...
ABSTRACT Ovarian cancer (OC) is the deadliest gynecologic malignancy, which is mainly due to late-stage diagnosis and chemotherapy resistance. Therefore, new and more effective treatments are urgently needed. The in vitro effects of Panobinostat (LBH), a histone deacetylase inhibitor that exerts pleiotropic antitumor effects but induces autophagy, in combination with Chloroquine (CQ), an autophagy inhibitor that avoid this cell survival mechanism, were evaluated in 4 OC cell lines. LBH and CQ in...
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#1Tiane Chen (JHUSOM: Johns Hopkins University School of Medicine)
#2Maged Zeineldin (JHUSOM: Johns Hopkins University School of Medicine)
Last. Tatianna Larman (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 2
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Although much is known about the gene mutations required to drive colorectal cancer (CRC) initiation, the tissue-specific selective microenvironments in which neoplasia arises remains less characterized. Here, we determined whether modulation of intestinal stem cell niche morphogens alone can exert a neoplasia-relevant selective pressure on normal colonic epithelium. Using adult stem cell-derived murine colonic epithelial organoids (colonoids), we employed a strategy of sustained withdrawal of e...
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#1Sandra N. Freiberger (UZH: University of Zurich)H-Index: 12
#2Muriel Brada (UZH: University of Zurich)H-Index: 4
Last. Niels J. Rupp (UZH: University of Zurich)H-Index: 17
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Abstract Diagnosis of salivary gland neoplasms is often challenging due to their high morphological diversity and overlaps. Several recurrent molecular alterations have been described recently, which can serve as powerful diagnostic tools and potential therapeutic targets (e.g. NTRK or RET fusions). However, current sequential molecular testing can be expensive and time consuming. In order to facilitate the diagnosis of salivary gland neoplasms, we designed an all-in-one RNA-based next generatio...
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#1Huaqin Yuan (Nanjing Medical University)H-Index: 4
#2Xiaoxin Meng (Nanjing Medical University)H-Index: 1
Last. Yanhong Gu (Nanjing Medical University)H-Index: 24
view all 10 authors...
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#1Shanwen Chen (PKU: Peking University)H-Index: 15
#2Dingfang Bu (PKU: Peking University)H-Index: 6
Last. Pengyuan Wang (PKU: Peking University)H-Index: 15
view all 9 authors...
Abstract Increased xCT and transsulfuration pathway has been associated with metabolic reprogramming of colorectal cancer. However, the correlation between these 2 events and the underlying molecular mechanism remains obscure. xCT expression was determined in tissue microarrays of colorectal cancer. RNA sequencing and functional assays in vitro was adopted to delineate the involvement of transsulfuration pathway in the proper function of xCT in maintaining the chemoresistant phenotype. The synth...
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