Response of eosinophilic oesophagitis to proton pump inhibitors is associated with impedance‐pH parameters implying anti‐reflux mechanism of action

Summary Background Proton pump inhibitors (PPIs) are effective therapies for eosinophilic oesophagitis (EoE), but the mechanism of action is uncertain. At on‐PPI impedance‐pH monitoring, improvement in oesophageal chemical clearance assessed with post‐reflux swallow‐induced peristaltic wave (PSPW) index characterises PPI‐responsive EoE and reflux disease. Off‐PPI, higher efficacy of the oesophago‐salivary reflex as measured with PSPW‐associated...