Leonardo Frazzoni
University of Bologna
Internal medicineRadiologySurgeryRandomized controlled trialProspective cohort studyHeartburnGERDEsophagusColonoscopyEndoscopyHigh resolution manometryImpedance–pH monitoringDiseaseProton-pump inhibitorIn patientRefluxConfidence intervalColorectal cancerMedicineGastroenterologyMeta-analysis
Publications 185
#1Leonardo FrazzoniH-Index: 21
#2Marzio FrazzoniH-Index: 31
Last. Rocco Maurizio ZagariH-Index: 29
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OBJECTIVE To validate Lyon Consensus criteria for diagnosing gastro-oesophageal reflux disease (GORD) by reflux monitoring. DESIGN Manual review of impedance-pH tracings from patients with proton pump inhibitor (PPI)-dependent heartburn, evaluated off PPI. Acid exposure time (AET) thresholds defined by the Lyon Consensus and impedance parameters were investigated, namely, total refluxes (TRs), postreflux swallow-induced peristaltic wave (PSPW) index and mean nocturnal baseline impedance (MNBI). ...
#1Julia Arribas (University of Porto)H-Index: 1
#2Giulio Antonelli (Sapienza University of Rome)H-Index: 13
Last. Mário Dinis-Ribeiro (University of Porto)H-Index: 57
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Objective Artificial intelligence (AI) may reduce underdiagnosed or overlooked upper GI (UGI) neoplastic and preneoplastic conditions, due to subtle appearance and low disease prevalence. Only disease-specific AI performances have been reported, generating uncertainty on its clinical value. Design We searched PubMed, Embase and Scopus until July 2020, for studies on the diagnostic performance of AI in detection and characterisation of UGI lesions. Primary outcomes were pooled diagnostic accuracy...
9 CitationsSource
#1Marzio FrazzoniH-Index: 31
#2Leonardo Frazzoni (UNIBO: University of Bologna)H-Index: 21
Last. Edoardo Savarino (UNIPD: University of Padua)H-Index: 60
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#1Marzio FrazzoniH-Index: 31
#2Leonardo Frazzoni (UNIBO: University of Bologna)H-Index: 21
Last. Edoardo Savarino (UNIPD: University of Padua)H-Index: 60
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BACKGROUND Proton pump inhibitors (PPIs) are effective therapies for eosinophilic oesophagitis (EoE), but the mechanism of action is uncertain. At on-PPI impedance-pH monitoring, improvement in oesophageal chemical clearance assessed with post-reflux swallow-induced peristaltic wave (PSPW) index characterises PPI-responsive EoE and reflux disease. Off-PPI, higher efficacy of the oesophago-salivary reflex as measured with PSPW-associated pH increments characterises PPI-responsive reflux disease a...
3 CitationsSource
Background and study aims The standard method for obtaining samples during endoscopic ultrasonography (EUS) is fine-needle aspiration (FNA), the accuracy of which can be affected by the presence of a cytopathologist in endoscopy room (rapid on-site evaluation [ROSE]). With the introduction of fine-needle biopsy (FNB), macroscopic on-site evaluation (MOSE) of a acquired specimen has been proposed. Only a few studies have evaluated the role of MOSE and in all except one, a 19G needle was used. Our...
1 CitationsSource
#1Leonardo Frazzoni (UNIBO: University of Bologna)H-Index: 21
#2Julia Arribas (University of Porto)H-Index: 1
Last. Mário Dinis-Ribeiro (Instituto Português de Oncologia Francisco Gentil)H-Index: 57
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AIMS Estimates on miss-rates for upper gastrointestinal neoplasia (UGIN) rely on registry data or old studies. Quality assurance programs for upper-GI endoscopy are not fully established due to the lack of the infrastructure to measure endoscopists' competence. We aimed at assessing endoscopists' accuracy for the recognition of UGIN exploiting the framework of Artificial Intelligence (AI) validation studies. METHODS Literature search among databases (PubMed/MEDLINE, EMBASE, Scopus) up to August ...
#1Salvatore ToloneH-Index: 27
#2Edoardo SavarinoH-Index: 60
Last. Ludovico DocimoH-Index: 22
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#1Marzio FrazzoniH-Index: 31
#2Leonardo FrazzoniH-Index: 21
Last. Edoardo SavarinoH-Index: 60
view all 10 authors...
Background: Hepatocellular carcinoma (HCC) is a major cause of morbidity and mortality among patients with cirrhosis. The risk of HCC recurrence after a complete response among patients treated with direct-acting antivirals (DAAs) has not been fully elucidated yet. Aim: To assess the risk of HCC recurrence after DAA therapy for hepatitis C virus (HCV). Methods: A systematic review across PubMed, Scopus and Scholar up to November 2020, including full-text studies that assessed the pattern of HCC ...
1 CitationsSource
#1Rocco Maurizio Zagari (UNIBO: University of Bologna)H-Index: 29
#2Leonardo Frazzoni (UNIBO: University of Bologna)H-Index: 21
Last. Franco Bazzoli (UNIBO: University of Bologna)H-Index: 58
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Helicobacter pylori infection still represents a major health issue, especially in developing countries, with an estimate of 4 billion of infected subjects in 2015. The increase of antibiotic resistance has undermined the efficacy of standard triple therapy leading to more complex regimens. This review summarizes recommendations of international guidelines and reports the most recent evidence from meta-analyses and clinical trials on the treatment of Helicobacter pylori infection. The choice of ...