Internal medicine

Quality of life (healthcare)

Intervention (counseling)

Population

Psychotherapist

Clinical psychology

Moderation

Meta-analysis

Mental health

Psychiatry

Surgery

Political science

Psychology

Randomized controlled trial

Psychological intervention

Systematic review

MEDLINE

Mindfulness

Acceptance and commitment therapy

Medicine

Social psychology

Environmental health

Nature Human Behaviour

Our current understanding of the efficacy of psychological interventions in improving mental states of wellbeing is incomplete. This study aimed to overcome limitations of previous reviews by examining the efficacy of distinct types of psychological interventions, irrespective of their theoretical underpinning, and the impact of various moderators, in a unified systematic review and meta-analysis. Four-hundred-and-nineteen randomized controlled trials from clinical and non-clinical populations (n = 53,288) were identified for inclusion. Mindfulness-based and multi-component positive psychological interventions demonstrated the greatest efficacy in both clinical and non-clinical populations. Meta-analyses also found that singular positive psychological interventions, cognitive and behavioural therapy-based, acceptance and commitment therapy-based, and reminiscence interventions were impactful. Effect sizes were moderate at best, but differed according to target population and moderator, most notably intervention intensity. The evidence quality was generally low to moderate. While the evidence requires further advancement, the review provides insight into how psychological interventions can be designed to improve mental wellbeing. This meta-analysis of 419 randomized controlled trials found that various types of psychological interventions could improve mental wellbeing in clinical and non-clinical populations. Effect sizes tended to be small to moderate and were influenced by various moderators.

A systematic review and meta-analysis of psychological interventions to improve mental wellbeing