Co-delivery of IOX1 and doxorubicin for antibody-independent cancer chemo-immunotherapy
Abstract
Anti-programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) antibodies are currently used in the clinic to interupt the PD-1/PD-L1 immune checkpoint, which reverses T cell dysfunction/exhaustion and shows success in treating cancer. Here, we report a histone demethylase inhibitor, 5-carboxy-8-hydroxyquinoline (IOX1), which inhibits tumour histone demethylase Jumonji domain-containing 1A (JMJD1A) and thus downregulates its...
Paper Details
Title
Co-delivery of IOX1 and doxorubicin for antibody-independent cancer chemo-immunotherapy
Published Date
Apr 23, 2021
Journal
Volume
12
Issue
1
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