PD-L1 tumor-intrinsic signaling and its therapeutic implication in triple-negative breast cancer
Abstract
Although the immune checkpoint role of programmed death ligand 1 (PD-L1) has been established and targeted in cancer immunotherapy, the tumor-intrinsic role of PD-L1 is less appreciated in tumor biology and therapeutics development, partly because of the incomplete mechanistic understanding. Here we demonstrate a potentially novel mechanism by which PD-L1 promotes the epithelial-mesenchymal transition (EMT) in triple-negative breast cancer...
Paper Details
Title
PD-L1 tumor-intrinsic signaling and its therapeutic implication in triple-negative breast cancer
Published Date
Apr 22, 2021
Journal
Volume
6
Issue
8
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