Abstract The study aimed to study the effects on structural characteristics and anti-inflammatory activities of algal sulfated polysaccharides isolated from Gracilaria lemaneiformis (GLP) after a combined treatment of UV irradiation (average irradiance of 6500 mJ/cm2) and H2O2 (50 mmol/L) for various time periods up to 60 minutes. After a 30-minute treatment, the molecular weight and particle size of GLP was decreased by 15 and 2.6 fold, respectively with small but significant decrease in the contents of total sugars, uronic acids and proteins. There seemed to have no starch and the presence of longer side chains of branches in the GLP samples before and after UV/H2O2 treatment based on the I2-KI assay. Scanning electron microscope and atomic force microscope analysis confirmed that the UV/H2O2 treatment could modify the surface morphology of GLP. GLP treated for 5 minutes possessed the strongest in vitro anti-inflammatory activity by inhibiting the production of nitric oxide, tumor necrosis factor-α and interleukin-6 by 60.49%, 62.81% and 36.29%, respectively in IEC-6 cells when compared to the model. Therefore, UV/H2O2 treatment had the potential to enhance the anti-inflammatory activity of algal sulfated polysaccharides.
This study aimed to investigate the possible mechanism of the protective effect of a sulfated polysaccharide (SP) from Gracilaria Lemaneiformis against colitis induced by dextran sulfate sodium (DSS). Balb/c mice were gavaged with SP for four weeks, then colon tissue, cecal contents and feces were collected for further analysis. Results showed that SP was effective for inhibiting colon shortening and oedema forming. It could alleviate colonic inflammation via down-regulating the expression of tu...
Abstract Ganoderma lucidum exhibits pronounced anti-inflammatory effects, polysaccharides and triterpenoids are regarded as major constituents displaying the anti-inflammatory activities, whether sterols contribute to this activity remains unclear. Herein Ganoderma lucidum sterols (GLS) were innovatively isolated by a single-step procedure, the profile of GLS was characterized by HPLC-ELSD and shown similar to that of sterols separated by a traditional method, but much higher in content. Further...
#1Xiao-Li Li(Hefei University of Technology)H-Index: 5
#2Run-Hui Ma(Hefei University of Technology)H-Index: 4
Last. Zhao-Jun Wei(Hefei University of Technology)H-Index: 5
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Abstract The present study emphasized on the anti-cancerous effects of dioscin and its underlying molecular mechanism in human endometrial cancer Ishikawa cells. Dioscin significantly suppressed the proliferation of Ishikawa cells at IC50 of 2.37 μM. Besides, dioscin could inhibit the proliferation of Ishikawa cells by blocking the G0/G1 cell cycle through up-regulation of p16, p21, and p27 and down-regulation of cycle-cellular protein (Cyclin A/D/E) and cyclin-dependent kinase (CDK2/4/6). Also,...
Abstract In this study, the impact of ultrasound irradiation on the structural characteristics and antioxidant properties of yellow tea polysaccharides with different molecular weights (Mw) were investigated. Native yellow tea polysaccharide containing YTPS-3N, YTPS-5N and YTPS-7N were prepared through precipitation with ethanol at various concentrations of 30%, 50%, and 70%, respectively, and irradiated with high intensity ultrasound (20 kHz) for 55 min to yield yellow tea polysaccharide includ...
#1Mingxing Nie(CAS: Chinese Academy of Sciences)H-Index: 3
#2Yulian Li(CAS: Chinese Academy of Sciences)H-Index: 13
Last. Jinhuai Liu(CAS: Chinese Academy of Sciences)H-Index: 86
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Abstract Ultrathin iron-cobalt oxide nanosheets (CoFe-ONSs) synthesized via a facile one-step routine by using NaBH4 as the reductant were used for H2O2 activation and tetracycline (TC) elimination. The CoFe-ONSs realized 83.5% removal of TC under the neutral conditions after 50 min with 0.3 g/L catalyst, 20 mM H2O2 and 50 mg/L TC. The effects of catalyst dosage, H2O2 concentration, initial pH, temperature, initial TC concentration, anions and water sources on TC degradation were studied. Hydrox...
#1Xiong Li(SCUT: South China University of Technology)H-Index: 3
#2Huang Shiming(SCUT: South China University of Technology)H-Index: 2
Last. Jin-hua Piao(SCUT: South China University of Technology)H-Index: 14
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A sulfated polysaccharide extracted from Gracilaria lemaneiformis (GLP) with a prominent effect in regulating lipid metabolism was isolated. The molecular weight was 31.5 kDa and it was composed mainly of galactose, glucose and xylose. Fourier-transform infrared (FT-IR) spectrum and nuclear magnetic resonance (NMR) analysis suggested that GLP was composed of the following repeating unit: [3-β-Gal-4(OSO3)-1→4-α-3,6-anhydrogal-2(OSO3)-1→]. GLP could significantly decrease serum total cholesterol, ...
Abstract Hydroxylated fullerene, Fullerol, has applied in many areas because of its high electron affinity and antioxidant potential, while it was few used in wastewater treatment. In this study, the mechanism involved in Fullerol accelerated regeneration of Fe(II) in the Fe(III)/H2O2 system under dark condition was investigated with chloramphenicol (CAP) as a model pollutant. In Fullerol/Fe(III)/H2O2 system, CAP removal was completely achieved at 60 min via a non-photochemical pathway. In addit...
#1Yeongjo Son(SNU: Seoul National University)H-Index: 2
#2Young Min Lee(SNU: Seoul National University)H-Index: 19
Last. Kyung-Duk Zoh(SNU: Seoul National University)H-Index: 34
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Abstract Tris (1-chloro-2-propyl) phosphate (TCPP) is a chlorinated organic phosphate used in various applications as a flame retardant and plasticizer. TCPP is a known suspected carcinogen and is not effectively removed by traditional water treatments such as biological, chlorination, and UV irradiation. In this study, the UV/H2O2 reaction was employed to degrade TCPP in water. TCPP was effectively degraded in the UV/H2O2 reaction by pseudofirst-order kinetics. The second-order rate constant of...
Last. Zhiqi Lin(University of Birmingham)H-Index: 1
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Abstract This study explored the preventive effects of polysaccharide extracted from Gracilaria Lemaneiformis in mice with colitis induced by dextran sulfate sodium (DSS). FT-IR spectrum showed that SP was a typical sulfated polysaccharide (SP), which contained high content of S element in energy dispersive spectrometer (EDS) analysis. SP was mainly composed of (1 → 3)-linked glycosidic bonds. Our results showed that SP could improve physical conditions of mice via alleviating weight loss and ap...
#1Miao-Miao Liu(Hefei University of Technology)H-Index: 2
#2Run-Hui Ma(Hefei University of Technology)H-Index: 4
Last. Zhao-Jun Wei(Hefei University of Technology)H-Index: 5
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Abstract Epidemiologic evidence promote the inclusion of flavones in diet due to their inhibitory effects on certain types of cancers, particularly in women. Among the naturally occurring plant flavonoids, Apigenin 7-O-glucoside (AGL) is endowed with anti-inflammatory, anti-oxidant, and anti-cancer activities. However, its mechanism of action on cervical cancer, the fourth largest cancer in women, has not yet been clarified. In the current study, we have determined the effect of AGL on human cer...
Last. You-Jin Jeon(Jeju National University)H-Index: 79
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In the present study, the in vitro and in vivo anti-inflammatory effects of the sulfated polysaccharides isolated from Sargassum fulvellum (SFPS) were evaluated in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages and zebrafish. The results indicated that SFPS improved the viability of LPS-stimulated RAW 264.7 macrophages from 80.02 to 86.80, 90.09, and 94.62% at the concentration of 25, 50, and 100 µg/mL, respectively. Also, SFPS remarkably and concentration-dependently decreased the pr...
