Molecular Characterization of Residual Bladder Cancer after Neoadjuvant Pembrolizumab

In patients with muscle-invasive urothelial bladder cancer (MIBC), molecular alterations in immunotherapy-resistant tumors found at radical cystectomy (RC) remain largely unstudied.To investigate the biology of pembrolizumab-resistant tumors in comparison to an RC cohort treated without any systemic therapy and a cohort of neoadjuvant chemotherapy (NAC)-treated tumors.Transcriptome-wide expression profiling was performed on 26 RC samples from...