Efflux Limits Tumor Drug Delivery Despite Disrupted BBB

Apparent blood–brain barrier (BBB) disruption is common in glioblastoma (GBM), but has not translated to improved drug delivery efficacy. Recently, de Gooijer et al. demonstrated that efflux transporters can have a prominent role in limiting drug delivery. These transport systems contribute to ineffective drug delivery to tumor cells in the brain. Apparent blood–brain barrier (BBB) disruption is common in glioblastoma (GBM), but has not...