The catalytic subunit of Plasmodium falciparum casein kinase 2 is essential for gametocytogenesis
Abstract
Casein kinase 2 (CK2) is a pleiotropic kinase phosphorylating substrates in different cellular compartments in eukaryotes. In the malaria parasite Plasmodium falciparum , PfCK2 is vital for asexual proliferation of blood-stage parasites. Here, we applied CRISPR/Cas9-based gene editing to investigate the function of the PfCK2α catalytic subunit in gametocytes, the sexual forms of the parasite that are essential for malaria transmission. We show...
Paper Details
Title
The catalytic subunit of Plasmodium falciparum casein kinase 2 is essential for gametocytogenesis
Published Date
Mar 12, 2021
Journal
Volume
4
Issue
1
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