Till S. Voss
University of Basel
PromoterHeterochromatinGeneGene silencingGenomeGene expressionRegulation of gene expressionAntigenic variationSubtelomereMalariaPlasmodium falciparumPlasmodiumEpigeneticsGeneticsGene familyParasite hostingTranscription factorBiologyHeterochromatin protein 1Cell biologyCRISPRGametocyte
55Publications
25H-index
2,761Citations
Publications 53
Newest
#1Felix Evers (Radboud University Nijmegen)H-Index: 2
#2Alfredo Cabrera-Orefice (Radboud University Nijmegen)H-Index: 11
Last. Taco W. A. Kooij (Radboud University Nijmegen)H-Index: 24
view all 0 authors...
Our current understanding of mitochondrial functioning is largely restricted to traditional model organisms, which only represent a fraction of eukaryotic diversity. The unusual mitochondrion of malaria parasites is a validated drug target but remains poorly understood. Here, we apply complexome profiling to map the inventory of protein complexes across the pathogenic asexual blood stages and the transmissible gametocyte stages of Plasmodium falciparum. We identify remarkably divergent compositi...
1 CitationsSource
#1Eva Hitz (University of Basel)H-Index: 3
Last. Till S. Voss (University of Basel)H-Index: 25
view all 7 authors...
Cyclic AMP (cAMP) signalling is crucial for the propagation of asexual malaria blood stage parasites. Recent work on Plasmodium falciparum demonstrated that phosphorylation of the invasion ligand AMA1 by the catalytic subunit of cAMP-dependent protein kinase A (PfPKAc) is an essential step during parasite invasion into red blood cells. However, the exact mechanisms regulating PfPKAc activity are only partially understood and PfPKAc function has not been extensively studied in gametocytes, the se...
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#1Marta Tibúrcio (Francis Crick Institute)H-Index: 3
#2Eva Hitz (Swiss TPH: Swiss Tropical and Public Health Institute)H-Index: 3
Last. Moritz Treeck (Francis Crick Institute)H-Index: 23
view all 9 authors...
Malaria is a mosquito-borne disease caused by apicomplexan parasites of the genus Plasmodium. Completion of the parasite's life cycle depends on the transmission of sexual stages, the gametocytes, from an infected human host to the mosquito vector. Sexual commitment occurs in only a small fraction of asexual blood-stage parasites and is initiated by external cues. The gametocyte development protein 1 (GDV1) has been described as a key facilitator to trigger sexual commitment. GDV1 interacts with...
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#1Eilidh Carrington (University of Basel)H-Index: 1
#2Roel H. M. Cooijmans (Radboud University Nijmegen)H-Index: 1
Last. Till S. Voss (University of Basel)H-Index: 25
view all 6 authors...
Summary Malaria parasites undergo a complex life cycle in the human host and the mosquito vector. The ApiAP2 family of DNA-binding proteins plays a dominant role in parasite development and life cycle progression. Most ApiAP2 factors studied to date act as transcription factors regulating stage-specific gene expression. Here, we characterised an ApiAP2 factor in Plasmodium falciparum that we termed PfAP2-HC. We demonstrate that PfAP2-HC specifically binds to heterochromatin throughout the genome...
Source
#1Eva Hitz (University of Basel)H-Index: 3
#2Olivia Grüninger (University of Basel)
Last. Till S. Voss (University of Basel)H-Index: 25
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Casein kinase 2 (CK2) is a pleiotropic kinase phosphorylating substrates in different cellular compartments in eukaryotes. In the malaria parasite Plasmodium falciparum, PfCK2 is vital for asexual proliferation of blood-stage parasites. Here, we applied CRISPR/Cas9-based gene editing to investigate the function of the PfCK2α catalytic subunit in gametocytes, the sexual forms of the parasite that are essential for malaria transmission. We show that PfCK2α localizes to the nucleus and cytoplasm in...
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#1Hai T. N. Bui (University of Basel)H-Index: 1
#2Armin Passecker (University of Basel)H-Index: 2
Last. Till S. Voss (University of Basel)H-Index: 25
view all 4 authors...
The human malaria parasite Plasmodium falciparum encodes a single ortholog of heterochromatin protein 1 (PfHP1) that plays a crucial role in the epigenetic regulation of various survival-related processes. PfHP1 is essential for parasite proliferation and the heritable silencing of genes linked to antigenic variation, host cell invasion, and sexual conversion. Here, we employed CRISPR/Cas9-mediated genome editing combined with the DiCre/loxP system to investigate how the PfHP1 chromodomain (CD),...
1 CitationsSource
#1Hai T. N. Bui (University of Basel)H-Index: 1
#1Bui Htn (Swiss TPH: Swiss Tropical and Public Health Institute)
Last. Till S. Voss (Swiss TPH: Swiss Tropical and Public Health Institute)H-Index: 25
view all 4 authors...
Abstract The human malaria parasite Plasmodium falciparum encodes a single ortholog of heterochromatin protein 1 (PfHP1) that plays a crucial role in the epigenetic regulation of various survival-related processes. PfHP1 is essential for parasite proliferation and the heritable silencing of genes linked to antigenic variation, host cell invasion and sexual conversion. Here, we employed CRISPR/Cas9-mediated genome editing combined with the DiCre/LoxP system to investigate how the PfHP1 chromodoma...
Source
#1Marta Tibúrcio (Francis Crick Institute)H-Index: 3
#2Eva Hitz (University of Basel)H-Index: 3
Last. Moritz Treeck (Francis Crick Institute)H-Index: 23
view all 9 authors...
Abstract Malaria is a mosquito-borne disease caused by apicomplexan parasites of the genus Plasmodium. Completion of the parasite’s life cycle depends on the transmission of sexual stages, the gametocytes, from an infected human host to the mosquito vector. Sexual commitment occurs in only a small fraction of asexual blood stage parasites and is initiated by external cues. The gametocyte development protein 1 (GDV1) has been described as a key facilitator to trigger sexual commitment. GDV1 inter...
3 CitationsSource
#1F. EversH-Index: 1
#1Felix EversH-Index: 2
Last. Taco W. A. KooijH-Index: 24
view all 9 authors...
Our current understanding of mitochondrial functioning is largely restricted to traditional model organisms, which only represent a fraction of eukaryotic diversity. The unusual mitochondrion of malaria parasites is a validated drug target but remains poorly understood. Here, we apply complexome profiling to map the inventory of protein complexes across the pathogenic asexual blood stages and the transmissible gametocyte stages of Plasmodium falciparum. We identify remarkably divergent compositi...
3 CitationsSource
#1Sylwia D. BoltrykH-Index: 3
#2Armin Passecker (University of Basel)H-Index: 2
Last. Till S. VossH-Index: 25
view all 9 authors...
Abstract The malaria parasite Plasmodium falciparum replicates inside erythrocytes in the blood of infected humans. During each replication cycle, a small proportion of parasites commits to sexual development and differentiates into gametocytes, which are essential for parasite transmission to other human hosts via the mosquito vector. Detailed molecular investigation of gametocyte biology and transmission has been hampered by difficulties in generating large numbers of these highly specialized ...
2 CitationsSource