Bone resorption and dietary calcium in pregnancy—a window to future maternal bone health

Published on Mar 4, 2021in Osteoporosis International3.864
· DOI :10.1007/S00198-021-05891-W
E. C. O’Brien2
Estimated H-index: 2
(UCD: University College Dublin),
Aisling A. Geraghty9
Estimated H-index: 9
(UCD: University College Dublin)
+ 2 AuthorsFionnuala M. McAuliffe57
Estimated H-index: 57
(UCD: University College Dublin)
BACKGROUND Pregnancy is characterized by increased bone turnover and reversible loss of bone mineral density (BMD) to meet fetal calcium demands. The long-term effect of bone turnover and maternal diet in pregnancy on maternal bone is not well established. OBJECTIVE We aimed to determine if an association exists between [1] bone resorption, [2] dietary calcium, and [3] serum 25-hydroxyvitamin D in pregnancy with maternal BMD 5-year postpartum. DESIGN This is a prospective, longitudinal study of 107 women recruited to the ROLO low glycemic index dietary intervention trial in pregnancy and followed-up at 13, 28, and 34 weeks' gestation and 5 years' postpartum. At 13 and 28 weeks' gestation, a biomarker of bone resorption, urine cross-linked N-telopeptide of type I collagen (uNTX), was measured. At the 5-year follow-up BMD was measured using dual-energy X-ray absorptiometry. Anthropometry, dietary intakes, and serum 25-hydroxyvitamin D were measured in pregnancy and at 5 years. Multiple linear regression, controlling for confounders, was used for analysis. RESULTS Mean BMD at 5 years was 1.208 g/cm2. In pregnancy, 24-34% reported dietary calcium intakes <800 mg/day. Vitamin D deficiency (< 30 nmol/L) was observed in 38-41% of women in pregnancy and in 29% of women at the 5-year follow-up. At 13 and 28 weeks' gestation, uNTX levels greater than the median were associated with 0.060 and 0.050 g/cm2 lower BMD 5 years later, respectively. Dietary calcium <800 mg/day in trimester 3 was associated with 0.072 g/cm2 lower BMD 5 years later. Vitamin D deficiency at 5 years, but not in pregnancy, was associated with lower BMD. CONCLUSION Higher bone resorption and low dietary calcium in pregnancy were associated with lower BMD 5 years later. These findings could enable the identification of women at risk of declining of BMD in later life, but further research is needed. Adequate dietary calcium should be advised in the antenatal setting to promote lifelong maternal bone health.
#1Mícheál Ó Breasail (University of Cambridge)H-Index: 1
#2Ann Prentice (University of Cambridge)H-Index: 2
Last. Kate A Ward (University of Cambridge)H-Index: 37
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At birth the neonatal skeleton contains 20-30 g Ca, it is hypothesized maternal bone mineral may be mobilized to support fetal skeletal development, though evidence of pregnancy-induced mineral mobilization is limited. We recruited healthy pregnant (n = 53) and non-pregnant non-lactating (NPNL, n = 37) women aged 30-45 years (mean 35.4 +/- 3.8 years) and obtained peripheral quantitative computed tomography (pQCT) and high-resolution pQCT (HR-pQCT) scans from the tibia and radius at 14-16 and 34-...
6 CitationsSource
#1Eileen C O'Brien (UCD: University College Dublin)H-Index: 9
#2Mark KilbaneH-Index: 13
Last. Fionnuala M. McAuliffe (UCD: University College Dublin)H-Index: 57
view all 6 authors...
Purpose Pregnancy is characterised by increased bone turnover, but high bone turnover with resorption exceeding formation may lead to negative maternal bone remodelling. Recent studies are conflicting regarding the effect of calcium on skeletal health in pregnancy. The aim of this study was to examine the seasonal effect of serum 25-hydroxyvitamin D (25OHD) and dietary calcium on a marker of bone resorption.
7 CitationsSource
#1I. Kyvernitakis (Goethe University Frankfurt)H-Index: 7
#1Ioannis Kyvernitakis (Goethe University Frankfurt)H-Index: 16
Last. P. Hadji (University of Marburg)H-Index: 16
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Summary Almost a quarter of patients with PAO will sustain a subsequent fracture; patients need to be informed about potential risks before deciding for further pregnancies.
21 CitationsSource
#1Eileen C O'Brien (UCD: University College Dublin)H-Index: 9
#2Elizabeth J. O’Sullivan (UCD: University College Dublin)H-Index: 10
Last. Fionnuala M. McAuliffe (UCD: University College Dublin)H-Index: 57
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#2Yejee Kim (CAU: Chung-Ang University)H-Index: 2
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#1Juliet E. Compston (University of Cambridge)H-Index: 91
#2A CooperH-Index: 8
Last. N Vine (University of Cambridge)H-Index: 1
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Introduction In 2008, the UK National Osteoporosis Guideline Group (NOGG) produced a guideline on the prevention and treatment of osteoporosis, with an update in 2013. This paper presents a major update of the guideline, the scope of which is to review the assessment and management of osteoporosis and the prevention of fragility fractures in postmenopausal women and men age 50 years or over.
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#1Orna O'Brien (UCD: University College Dublin)H-Index: 4
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Abstract Objective to qualitatively explore influences identified by overweight/obese pregnant women on food choices and physical activity (PA) behaviours; to determine the impact of pregnancy on these factors; and to inform development of future lifestyle interventions during pregnancy. Design cross-sectional interview study. Setting maternity hospital, Ireland. Participants pregnant women ( n =22), early pregnancy Body Mass Index > 25kg/m 2 Measures barriers to and facilitators of healthy eati...
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#1Sue A. Shapses (RU: Rutgers University)H-Index: 46
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#1Janis Baird (University of Southampton)H-Index: 29
#2Mary Barker (University of Southampton)H-Index: 30
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Background The nutritional status and health of mothers influence the growth and development of infants during pregnancy and postnatal life. Interventions that focus on improving the nutritional status and lifestyle of mothers have the potential to optimise the development of the fetus as well as improve the health of mothers themselves. Improving the diets of women of childbearing age is likely to require complex interventions that are delivered in a socially and culturally appropriate context....
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