Ki-67 regulates global gene expression and promotes sequential stages of carcinogenesis

Significance Ki-67 is a nuclear protein present in all proliferating vertebrate cells and is widely used as a marker in clinical cancer histopathology. However, its cellular functions have remained largely mysterious, and whether it plays any roles in cancer was unknown. In this work, we show genetically that Ki-67 is not required for cell proliferation in tumors, but it is required for all stages of carcinogenesis. The effects on cell...