Nutraceuticals in the Prevention of Neonatal Hypoxia-Ischemia: A Comprehensive Review of their Neuroprotective Properties, Mechanisms of Action and Future Directions.

Published on Mar 3, 2021in International Journal of Molecular Sciences4.556
· DOI :10.3390/IJMS22052524
Marta Reyes-Corral (CSIC: Spanish National Research Council), Noelia Sola-Idígora + 2 AuthorsPatricia Ybot-Gonzalez17
Estimated H-index: 17
Neonatal hypoxia–ischemia (HI) is a brain injury caused by oxygen deprivation to the brain due to birth asphyxia or reduced cerebral blood perfusion, and it often leads to lifelong limiting sequelae such as cerebral palsy, seizures, or mental retardation. HI remains one of the leading causes of neonatal mortality and morbidity worldwide, and current therapies are limited. Hypothermia has been successful in reducing mortality and some disabilities, but it is only applied to a subset of newborns that meet strict inclusion criteria. Given the unpredictable nature of the obstetric complications that contribute to neonatal HI, prophylactic treatments that prevent, rather than rescue, HI brain injury are emerging as a therapeutic alternative. Nutraceuticals are natural compounds present in the diet or used as dietary supplements that have antioxidant, anti-inflammatory, or antiapoptotic properties. This review summarizes the preclinical in vivo studies, mostly conducted on rodent models, that have investigated the neuroprotective properties of nutraceuticals in preventing and reducing HI-induced brain damage and cognitive impairments. The natural products reviewed include polyphenols, omega-3 fatty acids, vitamins, plant-derived compounds (tanshinones, sulforaphane, and capsaicin), and endogenous compounds (melatonin, carnitine, creatine, and lactate). These nutraceuticals were administered before the damage occurred, either to the mothers as a dietary supplement during pregnancy and/or lactation or to the pups prior to HI induction. To date, very few of these nutritional interventions have been investigated in humans, but we refer to those that have been successful in reducing ischemic stroke in adults. Overall, there is a robust body of preclinical evidence that supports the neuroprotective properties of nutraceuticals, and these may represent a safe and inexpensive nutritional strategy for the prevention of neonatal HI encephalopathy.
#1Lindiwe Sibeko (UMass: University of Massachusetts Amherst)H-Index: 8
#2Timothy Johns (McGill University)H-Index: 33
Abstract Ethnopharmacological relevance Cross-cultural comparison of plants used during lactation and the postpartum period offers insight into a largely overlooked area of ethnopharmacological research. Potential roles of phytochemicals in emerging models of interaction among immunity, inflammation, microbiome and nervous system effects on perinatal development have relevance for the life-long health of individuals and of populations in both traditional and contemporary contexts. Aim of the stu...
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#1Saurabh Mittal (Jamia Hamdard)H-Index: 2
#2Mohammad Kashif Iqubal (Jamia Hamdard)H-Index: 4
Last. Sanjula Baboota (Jamia Hamdard)H-Index: 39
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: Natural products are increasing used in preventing and treating various diseases. Mangiferin belongs to the xanthone family, and has potential antiangiogenic, anticancer, immunomodulatory and anti-inflammatory activity along with the antioxidant activity. It is also used in the treatment of cardiac problem, diabetes and neurodegenerative disease. Finding of various researchers proves that mangiferin has a broad spectrum therapeutic application. Motive of this review is to describe the various ...
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#1Nathan A. Shlobin (NU: Northwestern University)H-Index: 5
#2Melissa A. LoPresti (BCM: Baylor College of Medicine)H-Index: 4
Last. Sandi Lam (NU: Northwestern University)H-Index: 6
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OBJECTIVE Neural tube defects (NTDs) are common congenital neurological defects, resulting in mortality, morbidity, and impaired quality of life for patients and caregivers. While public health interventions that increase folate consumption among women who are or plan to become pregnant are shown to reduce folate-sensitive NTDs, public health policy reflecting the scientific evidence lags behind. The authors aimed to identify the types of policies applied, associated outcomes, and impact of fola...
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#1Hélène Roumes (University of Bordeaux)H-Index: 5
#2Ursule Dumont (University of Bordeaux)H-Index: 3
Last. Anne-Karine Bouzier-Sore (University of Bordeaux)H-Index: 18
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Hypoxic-ischemic (HI) encephalopathy remains a major cause of perinatal mortality and chronic disability in newborns worldwide (1–6 for 1000 births). The only current clinical treatment is hypother...
13 CitationsSource
#1Hadi Mohsenpour (Kermanshah University of Medical Sciences)H-Index: 1
#2Mirko PesceH-Index: 21
Last. Mohammad Hosein FarzaeiH-Index: 29
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Neonatal hypoxic-ischemic (HI) brain injury is one of the major drawbacks of mortality and causes significant short/long-term neurological dysfunction in newborn infants worldwide. To date, due to multifunctional complex mechanisms of brain injury, there is no well-established effective strategy to completely provide neuroprotection. Although therapeutic hypothermia is the proven treatment for hypoxic-ischemic encephalopathy (HIE), it does not completely chang outcomes in severe forms of HIE. Th...
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#1Mengxia WangH-Index: 1
#2Ying RongH-Index: 1
Last. Li Luo (Guangdong Pharmaceutical University)H-Index: 1
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#1Bing Wang (Johns Hopkins University)H-Index: 14
#2Ewa Kulikowicz (Johns Hopkins University)H-Index: 10
Last. Zeng Jin Yang (Johns Hopkins University)H-Index: 14
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The striatal, primary sensorimotor cortical, and thalamic neurons are highly vulnerable to hypoxia-ischemia (HI) in term newborns. In a piglet model of HI that exhibits similar selective regional vulnerability, we tested the hypothesis that early treatment with sulforaphane, an activator of the Nrf2 transcription factor, protects vulnerable neurons from HI injury. Anesthetized piglets (aged 3-7 days) were subjected to 45 min of hypoxia and 7 min of airway occlusion. At 15 min after resuscitation...
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#1Isadora D’Ávila Tassinari (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 2
#2Mirella Kielek Galvan Andrade (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 1
Last. Luciano Fraga (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 19
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Abstract Neonatal hypoxic–ischemic encephalopathy is a major cause of mortality and disability in newborns and the only standard approach for treating this condition is therapeutic hypothermia, which shows some limitations. Thus, putative neuroprotective agents have been tested in animal models. The present study evaluated the administration of lactate, a potential energy substrate of the central nervous system (CNS) in an animal model of hypoxia–ischemia (HI), that mimics in neonatal rats the b...
2 CitationsSource
#1Gabriella D'Angelo (UNIME: University of Messina)H-Index: 15
#2Laura Cannavò (UNIME: University of Messina)H-Index: 3
Last. Eloisa Gitto (UNIME: University of Messina)H-Index: 31
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#1Kai Le (NCU: Nanchang University)H-Index: 1
#2Zhiping Song (NCU: Nanchang University)H-Index: 1
Last. Zhen Feng (NCU: Nanchang University)H-Index: 3
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OBJECTIVE AND DESIGN Microglia stimulated by oxygen glucose deprivation (OGD) were treated with quercetin to investigate the effect on oxidative stress and the inflammatory response and to explore whether toll-like receptor 4 (TLR4) signaling was involved. In addition, the effect of quercetin on the neurological functions of neonatal mice with hypoxic-ischemic brain injury (HIBI) was examined. MATERIALS AND SUBJECTS Mouse BV2 microglial cells and postnatal day 7 neonatal mice were used. TREATMEN...
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