Patricia Ybot-Gonzalez
Spanish National Research Council
NeurulationNeural foldGeneAnatomyNeural crestEndocrinologyClosure (topology)Convergent extensionEmbryoNeural plateNeuroepithelial cellNeural tube defectPregnancyEctodermNeural tubeComputer scienceMedicineFloor plateBiologyCell biology
45Publications
17H-index
1,367Citations
Publications 34
Newest
#1Marta Reyes-Corral (CSIC: Spanish National Research Council)
Last. Patricia Ybot-GonzalezH-Index: 17
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Neonatal hypoxia–ischemia (HI) is a brain injury caused by oxygen deprivation to the brain due to birth asphyxia or reduced cerebral blood perfusion, and it often leads to lifelong limiting sequelae such as cerebral palsy, seizures, or mental retardation. HI remains one of the leading causes of neonatal mortality and morbidity worldwide, and current therapies are limited. Hypothermia has been successful in reducing mortality and some disabilities, but it is only applied to a subset of newborns t...
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#1Beatriz Fernández‐Santos (CSIC: Spanish National Research Council)
#2José Manuel Caro-Vega (CSIC: Spanish National Research Council)H-Index: 1
Last. Patricia Ybot-Gonzalez (CSIC: Spanish National Research Council)H-Index: 17
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BACKGROUND Neural tube closure is a complex developmental process that takes place in the early stages of embryogenesis and that is a key step in neurulation. In mammals, the process by which the neural plate generates the neural tube requires organized cell movements and tissue folding, and it terminates with the fusion of the apposed ends of the neural folds. RESULTS Here we describe how almost identical cellular and molecular machinery is used to fuse the spinal neural folds as that involved ...
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#2Noelia Sola-Idígora (CSIC: Spanish National Research Council)
Last. Joan Montaner (CSIC: Spanish National Research Council)H-Index: 70
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Perinatal and pediatric diseases related to neurovascular disorders cause significant problems during life, affecting a population with a long life expectancy. Early diagnosis and assessment of the...
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#1Beatriz López-Escobar (CSIC: Spanish National Research Council)H-Index: 2
#2Rut Fernández-Torres (University of Huelva)H-Index: 21
Last. Patricia Ybot-Gonzalez (CSIC: Spanish National Research Council)H-Index: 17
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The use of first and second generation antiepileptic drugs during pregnancy doubles the risk of major congenital malformations and other teratogenic defects. Lacosamide (LCM) is a third-generation antiepileptic drug that interacts with collapsing response mediator protein 2, a protein that has been associated with neurodevelopmental diseases like schizophrenia. The aim of this study was to test the potential teratogenic effects of LCM on developing embryos and its effects on behavioural/histolog...
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#1Matteo A. Molè (University of Cambridge)H-Index: 7
#2Gabriel L. Galea (UCL: University College London)H-Index: 19
Last. Andrew J. Copp (UCL: University College London)H-Index: 63
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Summary Epithelial fusion is a key process of morphogenesis by which tissue connectivity is established between adjacent epithelial sheets. A striking and poorly understood feature of this process is "zippering," whereby a fusion point moves directionally along an organ rudiment. Here, we uncover the molecular mechanism underlying zippering during mouse spinal neural tube closure. Fusion is initiated via local activation of integrin β1 and focal anchorage of surface ectoderm cells to a shared po...
10 CitationsSource
#1Beatriz López‐Escobar (University of Texas at Austin)H-Index: 1
#2Bogdan J. Wlodarczyk (University of Texas at Austin)H-Index: 28
Last. Patricia Ybot-Gonzalez (CSIC: Spanish National Research Council)H-Index: 17
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BACKGROUND: Abnormalities in maternal folate and carbohydrate metabolism have both been shown to induce neural tube defects (NTDs) in humans and animal models. Nevertheless, how these two factors might interact in the development of NTDs remains unclear. RESULTS: In specific mouse models and embryo culture systems, we assessed the effects of combining maternal diabetes with mutations in genes involved in folate transport and metabolism (methylenetetrahydrofolate reductase [Mthfr] and folic acid ...
2 CitationsSource
#1Juan M. Suárez-Rivero (CSIC: Spanish National Research Council)H-Index: 7
#2Mario de la Mata (CSIC: Spanish National Research Council)H-Index: 15
Last. José Antonio Sánchez-Alcázar (CSIC: Spanish National Research Council)H-Index: 34
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Abstract Familial Hypercholesterolemia (FH) is an autosomal co-dominant genetic disorder characterized by elevated low-density lipoprotein (LDL) cholesterol levels and increased risk for premature cardiovascular disease. Here, we examined FH pathophysiology in skin fibroblasts derived from FH patients harboring heterozygous mutations in the LDL-receptor. Fibroblasts from FH patients showed a reduced LDL-uptake associated with increased intracellular cholesterol levels and coenzyme Q10 (CoQ10) de...
8 CitationsSource
#1Beatriz López-Escobar (CSIC: Spanish National Research Council)H-Index: 2
#2José Manuel Caro-Vega (CSIC: Spanish National Research Council)H-Index: 1
Last. Patricia Ybot-Gonzalez (CSIC: Spanish National Research Council)H-Index: 17
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The last stage of neural tube (NT) formation involves closure of the caudal neural plate (NP), an embryonic structure formed by neuromesodermal progenitors and newly differentiated cells that becomes incorporated into the NT. Here we show that as cell specification progresses, neuromesodermal progenitors and their progeny undergo significant changes in shape prior to their incorporation into the NT. The caudorostral progression towards differentiation is coupled to a gradual reliance on a unique...
14 CitationsSource
#1Suleva Povea-Cabello (CSIC: Spanish National Research Council)H-Index: 6
#2Manuel Oropesa-Ávila (CSIC: Spanish National Research Council)H-Index: 14
Last. José Antonio Sánchez-Alcázar (CSIC: Spanish National Research Council)H-Index: 34
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During apoptosis, cells undergo characteristic morphological changes in which the cytoskeleton plays an active role. The cytoskeleton rearrangements have been mainly attributed to actinomyosin ring contraction, while microtubule and intermediate filaments are depolymerized at early stages of apoptosis. However, recent results have shown that microtubules are reorganized during the execution phase of apoptosis forming an apoptotic microtubule network (AMN). Evidence suggests that AMN is required ...
31 CitationsSource
#1Ana Cañete (CSIC: Spanish National Research Council)H-Index: 6
#2Valentine Comaills (CSIC: Spanish National Research Council)H-Index: 11
Last. María José Sánchez (CSIC: Spanish National Research Council)H-Index: 87
view all 10 authors...
Spanish Ministry of Economy and Competitiveness (Grant IDs: BFU2010- 15801, CSD-2007-00008), Junta de Andalucia Regional Government (Grant ID: CVI-295), European Regional Development Funds, Wellcome Trust, Medical Research Council
6 CitationsSource