Original paper
Facilitative lysosomal transport of bile acids alleviates ER stress in mouse hematopoietic precursors
Abstract
Mutations in human equilibrative nucleoside transporter 3 (ENT3) encoded by SLC29A3 results in anemia and erythroid hypoplasia, suggesting that ENT3 may regulate erythropoiesis. Here, we demonstrate that lysosomal ENT3 transport of taurine-conjugated bile acids (TBA) facilitates TBA chemical chaperone function and alleviates endoplasmic reticulum (ER) stress in expanding mouse hematopoietic stem and progenitor cells (HSPCs). Slc29a3 −/− HSPCs...
Paper Details
Title
Facilitative lysosomal transport of bile acids alleviates ER stress in mouse hematopoietic precursors
Published Date
Feb 23, 2021
Journal
Volume
12
Issue
1
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Notes
History