Back Cover: Potent Trivalent Inhibitors of Thrombin through Hybridization of Salivary Sulfopeptides from Hematophagous Arthropods (Angew. Chem. Int. Ed. 10/2021)

A novel class of trivalent thrombin inhibitor is reported by Pedro José Barbosa Pereira, Richard J. Payne, and co-workers in their Research Article on page 5348. These inhibitors were rationally designed by hybridizing native sulfopeptide thrombin inhibitors from three different invertebrates: variegin from a bont tick, anophelin from the Anopheles mosquito, and TTI from the tsetse fly. When fused using bidirectional peptide synthesis and...