Last. Chunying Chen(CAS: Chinese Academy of Sciences)H-Index: 100
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Nanozyme-based tumor catalytic therapy is an emerging therapeutic method with high reactivity in response to tumor microenvironment (TME). To overcome the current limitations of deficient catalytic activity of nanozymes, we studied the contributing factors of enzymatic activity based on non-metallic atom doping and irradiation. Except for the chemical state of transition metal element, we demonstrated that nitrogen doping significantly enhanced the peroxidase (POD) activity of Ti-based nanozymes...
Positioning essential elements of photodynamic therapy (PDT) near to mitochondria can conquer the rigorous spatiotemporal limitations of reactive oxygen species (ROS) transfer and make considerable differences in PDT. However, precise accumulation of photosensitizer (PS) and oxygen within mitochondria is still challenging. We simultaneously encapsulated hexyl 5-aminolevulinate hydrochloride (HAL) and 3-bromopyruvic acid (3BP) into microparticles collected from X-ray-irradiated tumor cells (X-MP)...
Last. Yuefei Ruan(City University of Hong Kong)H-Index: 14
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Atomically dispersed metal-nitrogen sites show great prospect for the oxygen reduction reaction (ORR), whereas the unsatisfactory adsorption-desorption behaviors of oxygenated intermediates on the metal centers impede improvement of the ORR performance. We propose a new conceptual strategy of introducing sacrificial bonds to remold the local coordination of Fe-N x sites, via controlling the dynamic transformation of the Fe-S bonds in the Fe-N-C single-atom catalyst. Spectroscopic and theoretical...
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