Last. Huige Zhou(Center for Excellence in Education)H-Index: 14
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Nanozyme-based tumor catalytic therapy is an emerging therapeutic method with high reactivity in response to tumor microenvironment (TME). To overcome the current limitations of deficient catalytic activity of nanozymes, we studied the contributing factors of enzymatic activity based on non-metallic atom doping and irradiation. Except for the chemical state of transition metal element, we demonstrated that nitrogen doping significantly enhanced the peroxidase (POD) activity of Ti-based nanozymes...
Last. Hong Liu(UJN: University of Jinan)H-Index: 160
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Oxide-based afterglow materials were usually produced through high-temperature treatment (> 1000 °C), which brought both considerable energy consumption and safety risk to manufacturer. Here, we report the growth of a halide-based double perovskite, Cs 2 Na x Ag 1-x InCl 6 :y%Mn, via a facile hydrothermal reaction at 180 °C. Through a co-doping strategy of both Na + and Mn 2+ , the as-prepared crystals exhibited a red afterglow featuring a high color purity (~ 100%) and a long duration time (> 5...
A reagent-controlled stereodivergent carbocyclisation of aryl aldimine-derived, photocatalytically-generated, α-amino radicals possessing adjacent conjugated alkenes, affording either bicyclic or tetracyclic products, is described. Under net reductive conditions using commercial Hantzsch ester, the α-amino radical species underwent a single stereoselective cyclisation to give trans-configured amino-indane structures in good yield, whereas using a substituted Hantzsch ester as a milder reductant ...
Hydrazine is a chemical of utmost importance in our society, either for organic synthesis or energy use. The direct conversion of NH3 to hydrazine is highly appealing, but it remains a very difficult task because the degradation of hydrazine is thermodynamically more feasible than the cleavage of the N-H bond of NH3 . As a result, any catalyst capable of activating NH3 will thus unavoidably decompose N2 H4 . Here we show that cavitation bubbles, created by ultrasonic irradiation of aqueous NH3 a...
Proton transfer proceeding via tunneling is a fundamental quantum-mechanical phenomenon.Here we report rotational spectroscopy measurements of this process in thecomplex of the formic acid dimer with fluorobenzene. The assignment of the spectrumindicates that this complex exists in the form of a - stacked structure. Each rotationaltransition of the parent isotopologue exhibits a splitting feature. Isotopic substitution experimentsreveal that the spectral splitting results from double-proton tran...
Last. Panke Zhang(NU: Nanjing University)H-Index: 8
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Recent developments concerning large protein nanopores suggest a new approach to structure profiling of native folded proteins. In this work, the large vestibule of Mycobacterium smegmatis porin A (MspA) and calmodulin (CaM), a Ca2+-binding protein were used in the direct observation of the protein structure. Three conformers including the Ca2+-free, Ca2+-bound and target peptide-bound states of CaM were unambiguously distinguished. A disease related mutant, CaM D129G was also discriminated by M...
Last. Shaolin Zhu(NU: Nanjing University)H-Index: 20
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Regio- and enantioselective hydroarylamination, hydroalkylamination and hydroamidation of styrenes have been developed by NiH catalysis with a simple bioxazoline ligand under mild conditions. A wide range of enantioenriched benzylic arylamines, alkylamines and amides can be easily accessed by nitroarenes, hydroxylamines and dioxazolones respectively as amination reagents. The chiral induction in these reactions is proposed to proceed through an enantiodifferentiating syn-hydronickellation step.
Last. Cyrille Boyer(UNSW: University of New South Wales)H-Index: 90
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This work presents the synthesis of a novel photosensitive acrylate monomer for use as both a self-catalyst in the photoinduced electron/energy transfer - reversible addition fragmentation chain transfer (PET-RAFT) polymerisation process and a photosensitiser (PS) for antibacterial applications. A range of hydrophilic, cationic, and antimicrobial formulations are explored to compare the antibacterial effects between charged and non-charged polymers. Covalent attachment of catalyst to well-define...