Designing biocompatible protein nanoparticles for improving the cellular uptake and antioxidation activity of tetrahydrocurcumin

Tetrahydrocurcumin (THC) is a natural molecule with anticancerous, antioxidant and other beneficial activities. However, its low aqueous solubility leads to poor bioavailability. Sodium caseinate (NaCas) is an ideal natural protein carrier with amphiphilic and non-toxic properties, which provides a new possibility for improving the aqueous solubility of THC. In this study, THC loaded protein nanoparticles ([email protected]) were successfully...