Clinically relevant mutations in core metabolic genes confer antibiotic resistance

Science56.90
Volume: 371, Issue: 6531
Published: Feb 19, 2021
Abstract
Although metabolism plays an active role in antibiotic lethality, antibiotic resistance is generally associated with drug target modification, enzymatic inactivation, and/or transport rather than metabolic processes. Evolution experiments of Escherichia coli rely on growth-dependent selection, which may provide a limited view of the antibiotic resistance landscape. We sequenced and analyzed E. coli adapted to representative antibiotics at...
Paper Details
Title
Clinically relevant mutations in core metabolic genes confer antibiotic resistance
Published Date
Feb 19, 2021
Journal
Volume
371
Issue
6531
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.