Original paper
High-throughput phenotypic screen and transcriptional analysis identify new compounds and targets for macrophage reprogramming
Abstract
Macrophages are plastic and, in response to different local stimuli, can polarize toward multi-dimensional spectrum of phenotypes, including the pro-inflammatory M1-like and the anti-inflammatory M2-like states. Using a high-throughput phenotypic screen in a library of ~4000 FDA-approved drugs, bioactive compounds and natural products, we find ~300 compounds that potently activate primary human macrophages toward either M1-like or M2-like state,...
Paper Details
Title
High-throughput phenotypic screen and transcriptional analysis identify new compounds and targets for macrophage reprogramming
Published Date
Feb 3, 2021
Journal
Volume
12
Issue
1
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Notes
History