Original paper
DDR1-induced neutrophil extracellular traps drive pancreatic cancer metastasis
Abstract
Pancreatic ductal adenocarcinoma (PDAC) tumors are characterized by a desmoplastic reaction resulting in dense deposition of collagen that is known to promote cancer progression. A central mediator of protumorigenic collagen signaling is the receptor tyrosine kinase discoid domain receptor 1 (DDR1). DDR1 is a critical driver of a mesenchymal and invasive cancer cell PDAC phenotype. Previous studies have demonstrated that genetic or pharmacologic...
Paper Details
Title
DDR1-induced neutrophil extracellular traps drive pancreatic cancer metastasis
Published Date
Sep 8, 2021
Journal
Volume
6
Issue
17
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Notes
History