A unique esophageal extracellular matrix proteome alters normal fibroblast function in severe eosinophilic esophagitis

Eosinophilic esophagitis (EoE) is a chronic TH2 disorder complicated by tissue fibrosis and loss of esophageal luminal patency. The fibrostenotic esophagus does not respond well to therapy, but profibrotic therapeutic targets are largely unclear.Our aim was to utilize proteomics and primary cells as a novel approach to determine relevant profibrotic factors.We utilized primary esophageal EoE and normal fibroblasts, their derivative extracellular...