Seema S. Aceves
University of California, San Diego
Internal medicinePathologyDermatologyImmunologyAllergyFood allergyAsthmaInflammationGERDEosinophilEosinophiliaEsophagusDiseaseMEDLINEEosinophilicEsophagitisEsophageal diseaseFibrosisElimination dietEosinophilic esophagitisClinical trialMedicineBiologyGastroenterology
Publications 194
#1Wonhee Woo (UCSD: University of California, San Diego)
#2Seema S. AcevesH-Index: 40
PURPOSE OF REVIEW The purpose of this review is to provide the current understanding of the role of allergens/antigens, the use of allergy testing, and to elucidate the role of the allergist in the management of eosinophilic esophagitis (EoE). RECENT FINDINGS EoE is a T2 immune disorder that is part of the atopic march. EoE patients commonly have multiple concurrent allergic disorders. Recent studies demonstrate that, like other allergic diseases, epithelial barrier dysfunction plays a key role ...
#1Ekaterina Safroneeva (University of Bern)H-Index: 26
#2Zhaoxing Pan (Boston Children's Hospital)H-Index: 29
Last. Glenn T. Furuta (University of Colorado Denver)H-Index: 71
view all 25 authors...
BACKGROUND AND AIMS Esophageal dilation improves dysphagia but not inflammation in eosinophilic esophagitis (EoE) patients. We investigated if dilation modifies the association between symptoms and esophageal eosinophil count (eos/hpf). METHODS Adults enrolled in a multisite, prospective Consortium of Gastrointestinal Eosinophilic Disease Researchers OMEGA observational study (NCT02523118) completed the symptom-based EoE activity index (EEsAI) patient-reported outcome instrument and underwent en...
#1Christopher Ma (U of C: University of Calgary)H-Index: 21
#2Alain M. Schoepfer (CHUV: University Hospital of Lausanne)H-Index: 59
Last. Noam Zevit (TAU: Tel Aviv University)H-Index: 15
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#1Kara KliewerH-Index: 5
#2Nirmala GonsalvesH-Index: 30
Last. Marc E. RothenbergH-Index: 131
view all 23 authors...
#1Claire BeveridgeH-Index: 3
Last. Kelly A. WhelanH-Index: 23
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ABSTRACT: Infection with SARS-CoV-2 can lead to COVID-19. The gastrointestinal tract is now an appreciated portal of infection. SARS-CoV-2 enters host cells via angiotensin converting enzyme-2 (ACE2) and the serine protease TMPRSS2. Eosinophilic gastrointestinal disorders are inflammatory conditions caused by chronic type 2 (T2) inflammation. However, the effects of the T2 atopic inflammatory milieu on SARS-COV-2 viral entry gene expression in the GI tract is poorly understood. We analyzed tissu...
1 CitationsSource
#1Mario C. ManresaH-Index: 1
Last. Seema S. AcevesH-Index: 40
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#1Lance Y. Hsieh (UCSD: University of California, San Diego)
#2Austin W. T. Chiang (UCSD: University of California, San Diego)H-Index: 8
Last. Seema S. AcevesH-Index: 40
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Abstract Background Eosinophilic esophagitis (EoE) is a chronic Th2 disorder complicated by tissue fibrosis and loss of esophageal luminal patency. The fibrostenotic esophagus does not respond well to therapy but pro-fibrotic therapeutic targets are largely unclear. Objective To utilize proteomics and primary cell as a novel approach to determine relevant pro-fibrotic factors. Methods We utilized primary esophageal EoE and normal fibroblasts, their derivative extracellular matrixes (ECMs), an ap...
#1Park Study Team (Boston Children's Hospital)H-Index: 1
#1Wanda Phipatanakul (Harvard University)H-Index: 56
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Abstract Asthma remains one of the most important challenges to pediatric public health in the US. A large majority of children with persistent and chronic asthma demonstrate aeroallergen sensitization, which remains a pivotal risk factor associated with the development of persistent, progressive asthma throughout life. In individuals with a tendency toward Type 2 inflammation, sensitization and exposure to high concentrations of offending allergens is associated with increased risk for developm...