Review paper
Asxl1 C-terminal mutation perturbs neutrophil differentiation in zebrafish
Abstract
ASXL1 is one of the most frequently mutated genes in malignant myeloid diseases. In patients with myeloid malignancies, ASXL1 mutations are usually heterozygous frameshift or nonsense mutations leading to C-terminal truncation. Current disease models have predominantly total loss of ASXL1 or overexpressed C-terminal truncations. These models cannot fully recapitulate leukemogenesis and disease progression. We generated an endogenous...
Paper Details
Title
Asxl1 C-terminal mutation perturbs neutrophil differentiation in zebrafish
Published Date
Jan 22, 2021
Journal
Volume
35
Issue
8
Pages
2299 - 2310
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