Microstructural Injury to Corpus Callosum and Intrahemispheric White Matter Tracts Correlate With Attention and Processing Speed Decline After Brain Radiation.

Published on Jan 4, 2021in International Journal of Radiation Oncology Biology Physics7.038
· DOI :10.1016/J.IJROBP.2020.12.046
Mia A Salans3
Estimated H-index: 3
(UCSD: University of California, San Diego),
Kathryn R. Tringale11
Estimated H-index: 11
(MSK: Memorial Sloan Kettering Cancer Center)
Sources
Abstract
Abstract Background The corpus callosum (CC) and intra-hemispheric white matter tracts (IHWM) subserve critical aspects of attention and processing speed. We analyzed imaging biomarkers of microstructural injury within these regions and association with attention/processing speed decline post-radiotherapy in primary brain tumor patients. Methods On a prospective clinical trial, 44 primary brain tumor patients underwent cognitive testing and MRI/diffusion-weighted imaging pre-radiotherapy, and 3-, 6-, and 12-months post-radiotherapy. CC (subregions; total) and IHWM tracts (left/right without CC; total) were autosegmented; tumor/tumor bed/edema were censored. Biomarkers included: volume changes (cc); mean diffusivity (MD, higher values indicate WM injury); fractional anisotropy (FA, lower values indicate WM injury). Reliable-change indices measured changes in attention (WAIS-IV digits-forward; D-KEFS-Trail-Making visual-scanning) and processing speed (WAIS-IV coding; D-KEFS-Trail-Making number-sequencing, letter-sequencing), accounting for practice effects. Linear mixed-effects models evaluated associations between 1) mean radiation dose and biomarkers (volume, MD, FA); 2) imaging biomarkers and neurocognitive performance. Statistics were corrected for multiple comparisons. Results Processing speed declined at 6 months (number-sequencing, letter-sequencing; p Conclusions The CC demonstrated radiation dose-dependent atrophy and WM injury. Microstructural injury within the CC and IHWM was associated with attention/processing speed decline after radiotherapy. These areas represent possible avoidance regions for preservation of attention/processing speed.
References57
Newest
#1Michelle D. Tibbs (UCSD: University of California, San Diego)H-Index: 5
#2Minh-Phuong Huynh-Le (UCSD: University of California, San Diego)H-Index: 12
Last. Jona A. Hattangadi-Gluth (UCSD: University of California, San Diego)H-Index: 23
view all 12 authors...
ABSTRACT Purpose To investigate the association between imaging biomarkers of radiation-induced white matter (WM) injury within perisylvian regions and longitudinal language decline in brain tumor patients. Methods and Materials Primary brain tumor patients (n=44) on a prospective trial underwent brain MRI, diffusion-weighted imaging, and language assessments of naming [Boston Naming Test (BNT)] and fluency [DKEFS-Category Fluency (DKEFS-CF)] at baseline, 3, 6, and 12-months post-fractionated ra...
Source
#1Michelle D. Tibbs (UCSD: University of California, San Diego)H-Index: 5
#2Minh-Phuong Huynh-Le (UCSD: University of California, San Diego)H-Index: 12
Last. Jona A. Hattangadi-Gluth (UCSD: University of California, San Diego)H-Index: 23
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ABSTRACT Background Primary brain tumor patients are vulnerable to depression and anxiety symptoms, which may affect their neurocognitive functioning. We performed a prospective longitudinal analysis to examine the association between depression and anxiety symptoms and domain-specific neurocognitive functioning in primary brain tumor patients receiving radiation therapy [RT]. Methods On a prospective trial, 54 primary brain tumor patients receiving RT underwent comprehensive neurocognitive eval...
Source
#1Paul D. Brown (Mayo Clinic)H-Index: 95
#2Vinai GondiH-Index: 26
Last. Deepak KhuntiaH-Index: 29
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PURPOSERadiation dose to the neuroregenerative zone of the hippocampus has been found to be associated with cognitive toxicity. Hippocampal avoidance (HA) using intensity-modulated radiotherapy dur...
Source
#1Hui Ling Yang (NTU: National Taiwan University)H-Index: 5
#2Hsin Chu (NDMC: National Defense Medical Center)H-Index: 22
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Source
#1Roshan Karunamuni (UCSD: University of California, San Diego)H-Index: 17
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Last. Jona A. Hattangadi-Gluth (UCSD: University of California, San Diego)H-Index: 23
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Introduction We investigated multi-domain baseline neurocognition of primary brain tumor patients prior to radiotherapy (RT), including clinical predictors of function and association between pre-RT and post-RT impairment on a prospective trial.
Source
#1Kathryn R. Tringale (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 11
#2Tanya T. NguyenH-Index: 18
Last. Jona A. Hattangadi-GluthH-Index: 23
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Abstract Purpose We used quantitative MRI to prospectively analyze the association between microstructural damage to memory-associated structures within the medial temporal lobe and longitudinal memory performance after brain radiotherapy (RT). Methods and Materials Primary brain tumor patients receiving fractionated brain RT were enrolled on a prospective trial (n=27). Patients underwent high resolution volumetric brain MRI, diffusion-weighted imaging, and neurocognitive testing prior to and 3,...
Source
#1Minh-Phuong Huynh-Le (UCSD: University of California, San Diego)H-Index: 12
#2Roshan Karunamuni (UCSD: University of California, San Diego)H-Index: 17
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Abstract Background and purpose The amygdalae are deep brain nuclei critical to emotional processing and the creation and storage of memory. It is not known whether the amygdalae are affected by brain radiotherapy (RT). We sought to quantify dose-dependent amygdala change one year after brain RT. Materials and methods 52 patients with primary brain tumors were retrospectively identified. Study patients underwent high-resolution, volumetric magnetic resonance imaging before RT and 1 year afterwar...
Source
#1Kathryn R. Tringale (UCSD: University of California, San Diego)H-Index: 11
#2Tanya T. Nguyen (UCSD: University of California, San Diego)H-Index: 18
Last. Carrie R. McDonald (UCSD: University of California, San Diego)H-Index: 39
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Abstract Background and purpose Executive function (EF) decline is common after brain radiation therapy (RT), yet the etiology is unclear. We analyzed the association between longitudinal changes in frontal lobe white matter microstructure and decline in EF following RT in brain tumor patients on a prospective clinical trial. Materials and methods Diffusion tensor imaging was obtained on 22 patients with brain tumors prior to RT, as well as 3- and 6-months post-RT, in a prospective, observationa...
Source
#1Lisa A. Jacobson (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 16
#2E. Mark Mahone (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 45
Last. M. Douglas Ris (BCM: Baylor College of Medicine)H-Index: 27
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ABSTRACTThe current study examined processing speed in children two years post-treatment for brain tumors (BT) with radiation therapy (RT) compared to those treated with without RT. Participants in...
Source
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