Protein corona, understanding the nanoparticle–protein interactions and future perspectives: A critical review

Proteins are biopolymers of highly varied structures taking part in almost all processes occurring in living cells. When nanoparticles (NPs) interact with proteins in biological environments, they are surrounded by a layer of biomolecules, mainly proteins adsorbing to the surfaces. This protein rich layer formed around NPs is called the “protein corona”. Consequential interactions between NPs and proteins are governed due to the characteristics...