Polyamide-6 (PA6) is a synthetic polymer that bears resemblance to collagen in its backbone and has excellent stability in human body fluid. Chitosan (CS) with the similar structure to that of the polysaccharides existing in the extracellular matrix, has a more suitable biodegradation rate for the formation of new-bone. Eelectrospun fiber have nanoscale structure, high porosity and large specific surface area, can simulate the structure and biological function of the natural extracellular matrix. To meet the requirements of mechanical properties and biocompatibility of bone tissue engineering, electrospun PA6/CS scaffolds were fabricated by electrospinning technology. The mineralized PA6/CS scaffolds were obtained through immersion in 1.5 × simulated body fluid (1.5SBF), which allowed the hydroxyapatite (HA) layer to grow into the thickness range under very mild reaction conditions without the need of a prior chemical modification of the substrate surface. The results showed that electrospun PA6/CS fibrous scaffolds in the diameter range of 60-260 nm mimic the nanostructure of the extracellular matrix (ECM). The tensile strength and modulus of 10PA6/CS fibrous scaffolds reach up to 12.67 ± 2.31 MPa and 95.52 ± 6.78 MPa, respectively. After mineralization, HA particles uniformly distributed on the surface of PA6/CS fibrous scaffolds in a porous honeycomb structure, and the content of mineral was about 40%. In addition, cell culture study indicated that the mineralized PA6/CS composite scaffolds were non-cytotoxic, and had a good biocompatibility and an ability to promote MC3T3-E1 cell attachment and proliferation.
Last. Binghong Luo(JNU: Jinan University)H-Index: 17
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Abstract We present here a porous poly (L-lactide)/chitosan (PLLA/CS) composite scaffold with micro/nano-fiber hierarchical structure that was innovatively fabricated by combining 3D printing and thermally induced phase separation technology. Moreover, bioactive quercetin (Qu) was chosen to further functionalize the PLLA/CS scaffold with polydopamine (PDA) layer. The final results showed that the hydrophilicity and mechanical properties of the resulting PLLA/CS-D/Qu scaffold were obviously super...
Abstract Amongst the natural polymers, chitin is the second most abundant, present mainly in fungi and exoskeleton of crustaceans. It forms a major part of the seafood waste as compiled and presented in this review and is de-acetylated to produce chitosan. Structure and properties of chitosan have been described. Biocompatible and biodegradable characteristics of chitosan have been well studied. In addition to the environmental sustainability associated with its use, the malleability of chitosan...
Last. Nageh K. Allam(The: American University in Cairo)H-Index: 36
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Electrospun nanofibrous materials serve as potential solutions for several biomedical applications as they possess the ability of mimicking the extracellular matrix (ECM) of tissues. Herein, we report on the fabrication of novel nanostructured composite materials for potential use in biomedical applications that require a suitable environment for cellular viability. Anodized TiO2 nanotubes (TiO2 NTs) in powder form, with different concentrations, were incorporated as a filler material into a ble...
Tissue engineering uses a combination of cell biology, chemistry, and biomaterials to fabricate three dimensional (3D) tissues that mimic the architecture of extracellular matrix (ECM) comprising diverse interwoven nanofibrous structure. Among several methods for producing nanofibrous scaffolds, electrospinning has gained intense interest because it can make nanofibers with a porous structure and high specific surface area. The processing and solution parameters of electrospinning can considerab...
Abstract Biomimicry, biomineralization, and bioregeneration technologies will pave the way for regenerative medicine toward better human health. Functional fibrous scaffold with extracellular matrix–like natural structure and the three-dimensional (3D) network is crucial to meet the complex requirements of cell and new bone tissue growth. In this study, we fabricated 3D fibrous hydroxyapatite scaffold (3D FHAS) with biomimicry, biomineralization, and bioregeneration functionalities toward the re...
This work focuses on the synthesis of undoped and doped lanthanum oxide nanoparticles (La2O3 NPs) by a simple co-precipitation method for the catalytic reduction of 4-nitrophenol (4-NP) using NaBH4 as a reducing agent. Their optical properties, morphologies, structure, chemical compositions and electronic properties were carefully characterized by XRD, FTIR, SEM, TEM, PL and UV–visible absorption spectroscopy. The SEM and TEM images showed various shape morphologies and sizes of the particles. T...
#1Shahia Khattak(Tianjin University of Science and Technology)H-Index: 1
#2Fazli Wahid(Tianjin University of Science and Technology)H-Index: 13
Last. Cheng Zhong(Tianjin University of Science and Technology)H-Index: 109
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The bacterial infections have always a serious problem to public health. Scientists are developing new antibacterial materials to overcome this problem. Polysaccharides are promising biopolymers due to their diverse biological functions, low toxicity, and high biodegradability. Chitin and chitosan have antibacterial properties due to their cationic nature, while cellulose/bacterial cellulose does not possess any antibacterial activity. Moreover, the insolubility of chitin in common solvents, the...
Abstract The advances in the field of biomaterials have led to several studies on alternative biocompatible devices and to their development focusing on their properties, benefits, limitations, and utilization of alternative resources. Due to their advantages like biocompatibility, biodegradability, and low cost, polysaccharides have been widely used in the development of hydrogels. Among the polysaccharides studied on hydrogels preparation, chitosan (pure or combined with natural/synthetic poly...
Last. Guangxi Zhai(SDU: Shandong University)H-Index: 1
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Abstract Electrospinning, as a nanotechnology, is able to produce polymeric fibers materials with nanoscale structure which are also named electrospun fibers material (EFM). These EFMs can be used in many biomedical applications such as wound dressing, tissue engineering, and medical textile materials. Over the last decades, electrospun nanofibers also have been applied to drug delivery such as orodispersible film, solid dispersion and various controlled release dosage forms due to many properti...