Biomedical Materials
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Photodynamic therapy (PDT) is a new technology for disease diagnosis and treatment in modern medical clinic. The main advantages of PDT are low toxicity and side effects, wide range of application, no drug resistance, and no obvious trauma in the treatment process. However, in order to achieve effective PDT, new photosensitizer carriers need to be constructed, which can selectively deliver PS into tumor tissues. In this work, a photoactivatable antibody-Ce6 conjugate ACC with dual-function to ta...
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#1Yoontae Kim (American Dental Association)H-Index: 4
#2Eun-Jin Lee (American Dental Association)H-Index: 1
Last. Stella Alimperti (American Dental Association)H-Index: 11
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#1Ali ShanaghiH-Index: 10
#2Ali Reza SouriH-Index: 7
Last. Paul K. Chu (CityU: City University of Hong Kong)H-Index: 96
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A Ta/TaN multilayered coating is deposited on plasma-nitridedAZ91 Mg alloy. The top TaN layer undergoes O2+Ar plasma etching to improve the antibacterial properties and Mg plasma immersion ion implantation (PIII) is performed to enhance the biocompatibility and wound healing capability. A uniform, compact, homogeneous, and columnar nanostructured Mg-PIII and plasma-etched TaN layer with a cluster size of about 17 nm, surface roughness of 0.28 nm, and needle morphology is observed. Although, plas...
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#1Yu Luo (ZJU: Zhejiang University)H-Index: 3
#2Shenyu Huang (ZJU: Zhejiang University)
Last. Lie Ma (ZJU: Zhejiang University)H-Index: 26
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Currently, valve replacement surgery is the only therapy for the end-stage valvular diseases because of the inability of regeneration for diseased heart valves. Bioprosthetic heart valves (BHVs), which are mainly derived from glutaraldehyde (GA) crosslinked porcine aortic heart valves or bovine pericardium, have been widely used in the last decades. However, it is inevitable that calcification and deterioration may occur within 10-15 years, which are still the main challenges for the BHVs in cli...
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#1Zichu Yin (ZSTU: Zhejiang Sci-Tech University)
#2Han Liu (ZSTU: Zhejiang Sci-Tech University)H-Index: 1
Last. Yurong Cai (ZSTU: Zhejiang Sci-Tech University)H-Index: 23
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Bio-adhesives are essential for wound healing because of their convenience and safety. Although widely used as biomaterials, silk fibroin (SF)'s further application as bio-adhesive is hindered due to its weak stickiness with tissue and slow gelation speed. Here, a dopamine-modified silk fibroin-based bio-adhesive is fabricated by using genipin as the chemical cross-linking agent. Furthermore, metal ions have been used to adjust the adhesion property of the bio-adhesive. The experimental results ...
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#1Peng Yang (Xidian University)
#2Zhuang Chen (Xidian University)
Last. Zhongliang Wang (Xidian University)H-Index: 22
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With the improvement of living standards, cancer has become a great challenge around the world during last decades, meanwhile, abundant nanomaterials have been developed as drug delivery system (DDS) or cancer theranostic agents (CTA) with their outstanding properties. However, low multifunctional efficiency and time-consuming synthesis limit their further applications. Nowadays, green chemistry, in particular, the concept of atom economy, has defined new criteria for the simplicity and efficien...
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#1Jing Ye (Sichuan University)
#2Zhenghua Xiao (West China Medical Center of Sichuan University)
Last. Gang Yang (Sichuan University)H-Index: 7
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Cardiomyocyte (CM) transplantation is a promising option for regenerating infarcted myocardium. However, poor cell survival and residence rates reduce the efficacy of cell transplantation. Gelatin (GA) hydrogel as a frequently-used cell carrier is a possible approach to increase the survival rate of CMs. In this study, microbial transglutaminase (mTG) and chemical crosslinkers glutaraldehyde (GTA), genipin (GP), and 1-ethyl-3-(3-dimethyl aminopropyl)-carbodiimide (EDC) were employed to prepare G...
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#1Qingmei Sun (Tongji University)
#2Yunqing Zhu (Tongji University)
Last. Jianzhong Du (Tongji University)
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Nanocarriers (NCs) for delivery anticancer therapeutics have been under development for decades. Although great progress has been achieved, the clinic translation is still in the infancy. The key challenge lies in the biological barriers which lie between the NCs and the target spots, including blood circulation, tumor penetration, cellular uptake, endo-/lysosomal escape, intracellular therapeutics release and organelle targeting. Each barrier has its own distinctive microenvironment and require...
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Biomedical engineering
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