First-in-Human Phase I Study of MP0250, a First-in-Class DARPin Drug Candidate Targeting VEGF and HGF, in Patients With Advanced Solid Tumors

Published on Jan 10, 2021in Journal of Clinical Oncology32.956
· DOI :10.1200/JCO.20.00596
Richard D. Baird24
Estimated H-index: 24
(University of Cambridge),
Constanza Linossi2
Estimated H-index: 2
(University of Cambridge)
+ 12 AuthorsAurelius Omlin34
Estimated H-index: 34
(HSG: University of St. Gallen)
Sources
Abstract
PURPOSEA first-in-human study was performed with MP0250, a DARPin drug candidate. MP0250 specifically inhibits both vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) with...
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// Ulrike Fiedler 1 , Savira Ekawardhani 1 , Andreas Cornelius 1 , Pat Gilboy 1, 2 , Talitha R. Bakker 1, 3 , Ignacio Dolado 1, 4 , Michael T. Stumpp 1 and Keith M. Dawson 1 1 Molecular Partners AG, Schlieren, Switzerland 2 Horizon Pharma, Dublin, Ireland 3 Amgen (Europe) GmbH, Zug, Switzerland 4 Roche, Basel, Switzerland Correspondence to: Keith M. Dawson, email: info@molecularpartners.com Keywords: VEGF, HGF, serum albumin, DARPin ® , patient-derived xenograft Received: July 13, 2017 Accepted:...
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