Increased self‐reported sleepiness is associated with larger brain volume and less ischemic brain injury in a community sample

Background Sleepiness has been associated with an increased risk of Alzheimer’s disease (AD) and vascular dementia, but few studies have investigated its association with markers of accelerated brain aging. We evaluated the association between sleepiness and MRI measures; and whether the apolipoprotein E4 ( APOE4 ) allele status moderates this relationship. Method We studied 492 participants (58.8 ± 8.8 years, 49.4%M) in the Framingham Heart...