Targeted graphene oxide for drug delivery as a therapeutic nanoplatform against Parkinson's disease.

Published on Mar 10, 2021in Biomaterials Science6.183
· DOI :10.1039/D0BM01765E
Sha Xiong5
Estimated H-index: 5
,
Jingshan Luo3
Estimated H-index: 3
+ 12 AuthorsTongkai Chen12
Estimated H-index: 12
(Guangzhou University of Chinese Medicine)
Sources
Abstract
There has been an exponential increase in the rate of incidence of Parkinson's disease (PD) with aging in the global population. PD, the second most common neurodegenerative disorder, results from damaged dopamine neurons in the substantia nigra pars compacta (SNpc), along with the deposition of abnormal α-synuclein (α-Syn), and the progressive degeneration of neurons in striatal regions. Despite extensive investigations to understand the pathophysiology of PD to develop effective therapies to restrict its progression, there is currently no cure for PD. Puerarin (Pue) is a natural compound with remarkable anti-PD properties. However, its poor pharmacological properties, including poor water solubility, inadequate bioavailability, and incomplete penetration of the blood-brain barrier (BBB) have restricted its use for the treatment of PD. Nevertheless, advancements in nanotechnology have revealed the potential advantages of targeted drug delivery into the brain to treat PD. Here, we used Pue-loaded graphene oxide (GO) nanosheets, which have an excellent drug-loading ability, modifiable surface functional groups, and good biocompatibility. Then, Pue was transported across the BBB into the brain using lactoferrin (Lf) as the targeting ligand, which could bind to the vascular endothelial receptor on the BBB. In vivo and in vitro results indicated that this multifunctional brain targeted drug delivery system (Lf-GO-Pue) was an effective and safe therapy for PD.
References51
Newest
#1Melissa J. Armstrong (UF: University of Florida)H-Index: 27
#2Michael S. Okun (UF: University of Florida)H-Index: 90
Importance Parkinson disease is the most common form of parkinsonism, a group of neurological disorders with Parkinson disease–like movement problems such as rigidity, slowness, and tremor. More than 6 million individuals worldwide have Parkinson disease. Observations Diagnosis of Parkinson disease is based on history and examination. History can include prodromal features (eg, rapid eye movement sleep behavior disorder, hyposmia, constipation), characteristic movement difficulty (eg, tremor, st...
138 CitationsSource
#1Olufemi A. Alamu (UWC: University of the Western Cape)H-Index: 1
#2Mariam Rado (UWC: University of the Western Cape)H-Index: 1
Last. David Fisher (UWC: University of the Western Cape)H-Index: 7
view all 4 authors...
Oxidative stress (OS) has been linked to blood–brain barrier (BBB) dysfunction which in turn has been implicated in the initiation and propagation of some neurological diseases. In this study, we profiled, for the first time, two endothelioma cell lines of mouse brain origin, commonly used as in vitro models of the blood–brain barrier, for their resistance against oxidative stress using viability measures and glutathione contents as markers. OS was induced by exposing cultured cells to varying c...
4 CitationsSource
#1Tongkai Chen (Guangzhou University of Chinese Medicine)H-Index: 12
#2Wei Liu (Guangzhou University of Chinese Medicine)H-Index: 8
Last. Xiaojia Chen (UM: University of Macau)H-Index: 19
view all 8 authors...
Recent work has highlighted the potential of puerarin (PU) as a valuable compound to treat Parkinson’s disease (PD), but its poor water solubility and bioavailability have constrained its utility. In this study, we sought to develop nanoparticles (NPs) which could be used to encapsulate PU, thereby extending its in vivo half-life and improving its bioavailability and accumulation in the brain to treat the symptoms of PD. We prepared spherical NPs (88.36 ± 1.67 nm) from six-armed star-shaped poly...
14 CitationsSource
#1Yating Zhang (Qingdao Agricultural University)H-Index: 2
#2Chuanfen Pu (Qingdao Agricultural University)H-Index: 2
Last. Qingjie Sun (Qingdao Agricultural University)H-Index: 31
view all 5 authors...
Abstract Gallic acid liposomes (GA-LIP) and gallic acid liposomes decorated with lactoferrin (LF-GA-LIP) were fabricated, and their physiochemical, in vitro digestion and antibacterial activity were analysed. The average particle size of LF-GA-LIP was larger than that of GA-LIP, and the former had a higher encapsulation efficiency and storage stability. Electrostatic interaction existed between lactoferrin and the phospholipid bilayer. Spherical structures of both were observed by transmission e...
24 CitationsSource
AbstractPueraria lobata (Willd.) Ohwi is a medicinal and edible homologous plant with a long history in China. Puerarin, the main component isolated from the root of Pueraria lobata, possesses a wi...
14 CitationsSource
#1Avinash Gothwal (Central University of Rajasthan)H-Index: 11
#2Hitesh Kumar (Central University of Rajasthan)H-Index: 4
Last. Umesh Gupta (Central University of Rajasthan)H-Index: 32
view all 7 authors...
Lower generation PAMAM dendrimers have immense potential of drug delivery with lesser toxicity, but these dendrimers yet need certain basic ameliorations. In this study, brain delivery potential of synthesized PAMAM-Lf (lower generation PAMAM and lactoferrin conjugate) loaded with memantine (MEM) was explored and evaluated in vitro and in vivo in the disease-induced mice model. The developed nano-scaffolds were characterized for size, zeta, and in-vitro release. Increase in the average size by 1...
8 CitationsSource
#1Qinjuan WuH-Index: 1
#2Mingfeng QinH-Index: 1
Last. Kun Zhang (Yangtze University)H-Index: 1
view all 3 authors...
AbstractIn this study, sevoflurane (SF) loaded, Fas ligand conjugated reduced graphene oxide (rGO) system is fabricated as a therapeutic agent to target brain ischaemic region. The fluorescence inv...
1 CitationsSource
#1Wei Tang (NIH: National Institutes of Health)H-Index: 31
#1Wei Tang (NIH: National Institutes of Health)H-Index: 79
Last. Xiaoyuan Chen (NIH: National Institutes of Health)H-Index: 162
view all 6 authors...
Brain cancer, especially the most common type of glioblastoma, is highly invasive and known as one of the most devastating and deadly neoplasms. Despite surgical and medical advances, the prognosis for most brain cancer patients remains dismal and the median survival rarely exceeds 16 months. Drug delivery to the brain is significantly hindered by the existence of the blood–brain barrier (BBB), which serves as a protective semi-permeable membrane for the central nervous system. Recent breakthrou...
86 CitationsSource
#1Chand Raza (Government College University)H-Index: 3
#2Rabia Anjum (Government College University)H-Index: 2
Last. Noor ul Ain Shakeel (Government College University)H-Index: 2
view all 3 authors...
Abstract Parkinson's disease is a progressive neurodegenerative disorder. The classical motor symptoms include resting tremors, bradykinesia, rigidity and postural instability and are accompanied by the loss of dopaminergic neurons and Lewy pathology. Diminished neurotransmitter level, oxidative stress, mitochondrial dysfunction and perturbed protein homeostasis over time worsen the disease manifestations in elderly people. Current management strategies aim to provide symptomatic relief and to s...
64 CitationsSource
#1Yibo Jin (Fudan University)H-Index: 2
#2Yunxiang Sun (Fudan University)H-Index: 16
Last. Guanghong Wei (Fudan University)H-Index: 36
view all 5 authors...
The aggregation of the amyloid-beta (Aβ) peptides into toxic β-sheet-rich oligomers, protofibrils and mature fibrils is the major pathological hallmark of Alzheimer's disease (AD). Inhibiting the β-sheet formation and fibrillization of Aβ peptides is considered an important treatment strategy for AD. Graphene oxide (GO) has attracted particular interest in the anti-aggregation of amyloid proteins due to its good ability of crossing the blood–brain barrier (BBB), low cytotoxicity and good biocomp...
10 CitationsSource
Cited By0
Newest