Biomaterials Science
Papers 2711
1 page of 272 pages (2,711 results)
#1Paula Camacho (Lehigh University)H-Index: 2
#2Anne Behre (Lehigh University)
Last. Lesley W. Chow (Lehigh University)H-Index: 16
view all 5 authors...
Functional repair of osteochondral (OC) tissue remains challenging because the transition from bone to cartilage presents gradients in biochemical and physical properties necessary for joint function. Osteochondral regeneration requires strategies that restore the spatial composition and organization found in the native tissue. Several biomaterial approaches have been developed to guide chondrogenic and osteogenic differentiation of human mesenchymal stem cells (hMSCs). These strategies can be c...
#1Maria SartoriH-Index: 17
#2Veronica BorsariH-Index: 20
Last. Milena FiniH-Index: 83
view all 7 authors...
Nowadays, direct bone anchored systems are an increasingly adopted approach in the therapeutic landscape for amputee patients. However, the percutaneous nature of these devices poses a major challenge to obtain a stable and lasting proper adhesion between the implant surface and the skin. A systematic review was carried out in three databases (PubMed, Scopus, Web of Science) to provide an overview of the innovative strategies tested with preclinical models (in vitro and in vivo) in the last ten ...
#1Gyeung Mi Seon (Yonsei University)H-Index: 7
#2Mi Hee Lee (Yonsei University)H-Index: 18
Last. Jong Chul Park (Yonsei University)H-Index: 39
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Despite the development of advanced tissue engineering substitutes, inflammation is still a significant problem that can arise from inflamed burn injuries, chronic wounds, or microbial diseases. Although topical wound dressing accelerates healing by minimizing or preventing the consequences of skin inflammation, there remains a need for the development of a novel substitute scaffold that can effectively eliminate immoderate inflammation and infection in the initial phase of the healing meachanis...
#1Cong Wang (ZJU: Zhejiang University)
#2Yunfan Xue (ZJU: Zhejiang University)H-Index: 4
Last. Jian Ji (ZJU: Zhejiang University)H-Index: 72
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Coating modification such as drug-eluting coating is one of the most important approaches for the functionalization of biomedical devices. However, the throughputs are limited in conventional coating methods and the concept of miniaturization is rarely fulfilled. A droplet microarray (DMA), as a unique high-throughput platform, can avoid cross-contamination and reduce the consumption of materials which is inherently suitable for coating research yet is difficult to apply with coating materials v...
#1Zhentao Yu (CAS: Chinese Academy of Sciences)
#2Y.P. Xu (CAS: Chinese Academy of Sciences)H-Index: 13
Last. Wantong Song (CAS: Chinese Academy of Sciences)H-Index: 29
view all 11 authors...
Cancer vaccines artificially stimulate the immune system against cancer and are considered the most promising treatment of cancer. However, the current progress in vaccine research against cancer is still limited and slow, partially due to the difficulties in identifying and obtaining tumor-specific antigens. Considering surgery as the first choice for tumor treatment in most cases, the authors evaluated whether the resected tumor can be directly used as a source of tumor antigens for designing ...
#1Ahmad Reza Bagheri (GU: Guangzhou University)
#1Ahmad BagheriH-Index: 26
Last. Jianbo Jia (GU: Guangzhou University)H-Index: 12
view all 7 authors...
In recent years, the number of patients diagnosed with cancer has been soaring. Therefore, the design, development, and implementation of new approaches for the diagnosis and therapy of different types of cancers have attracted an increasing amount of attention. To date, different methods have been used for cancer diagnosis and therapy with main drawbacks in terms of severe side effects, e.g., damaging healthy cells, the development of drug resistance and tumor recurrence. Therefore, there is an...
#1Liming Ruan (UNNC: The University of Nottingham Ningbo China)H-Index: 1
#2Gao Song (ZSTU: Zhejiang Sci-Tech University)H-Index: 6
Last. Guohua Jiang (ZSTU: Zhejiang Sci-Tech University)H-Index: 41
view all 8 authors...
The development of multifunctional nanoformulations (NFs) include several features in a single nanosystem for these devices to overcome the disadvantages of inefficiency and undesirable toxicity of traditional therapies and provide new opportunities in the management of tumors. Herein, multifunctional CaO2@Mn-PDA NFs with a core–shell structure, integrating the photothermal conversion properties of Mn-PDA, the chemodynamic properties of doped Mn ions, and relieving hypoxia in the tumor microenvi...
Mitochondria are reported to play a paramount role in tumorigenesis which positions them as an instrumental druggable target. However, selective drug delivery to cancer-localized mitochondria remains challenging. Herein, we report for the first time, the design, development and evaluation of a hepatic cancer-specific mitochondria-targeted dual ligated nanoscale metal–organic framework (NMOF) for cellular and mitochondrial sequential drug delivery. Surface functionalization was performed through ...
#2Jesus Garcia-Chica (University of Barcelona)H-Index: 1
Last. Hiroaki KinohH-Index: 22
view all 14 authors...
Carnitine palmitoyltransferase 1A (CPT1A) is a central player in lipid metabolism, catalyzing the first step to fatty acid oxidation (FAO). Inhibiting CPT1A, especially in the brain, can have several pharmacological benefits, such as in treating obesity and brain cancer. C75-CoA is a strong competitive inhibitor of CPT1A. However, due to its negatively charged nature, it has low cellular permeability. Herein, we report the use of poly-ion complex (PIC) micelles to deliver the specific CPT1A inhi...
#1Ren Jian (Tianjin Polytechnic University)
#2Jiang Fuxin (Tianjin Polytechnic University)
Last. Dai Fengying (Tianjin Polytechnic University)H-Index: 7
view all 9 authors...
Advanced drug vehicle exploitation and the sophisticated synergy mechanism revelation are two great difficulties in combination therapy. Compared with most readily available polymer micelles, some undiscovered complex chemical design principles limit the expanding research of polymer vesicles. Here, polycaprolactone (PCL)-g-Dextran vesicle that dextran brush steric hindrance guide PCL lamellae-aligned growth was synthesized. The effect of the glycometabolism multi-drug vesicle combination treatm...
Top fields of study
Organic chemistry
In vivo
Drug delivery