Biomaterials Science
Papers 2,833
1 page of 284 pages (2,833 results)
#1Qianqian Zhang (HNU: Hunan Normal University)
#2Jiawei Xu (HNU: Hunan Normal University)
Last. Zhonghua Liu (HNU: Hunan Normal University)
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Employing a peptide-based supramolecular photosensitizer nanofiber that combines the flexibility of a self-assembling short peptide and high spatiotemporal precision is a promising approach in photodynamic therapy (PDT). Herein, we developed a versatile multicomponent and multifunctional coordination self-assembling photosensitizer nanofiber based on the combination of a diphenylalanine (FF) short peptide, cell penetrating peptide 44 (CPP44) and 5-(4-aminophenyl)-10,15,20-triphenyl porphine (TPP...
#1Weifeng Shao (WMC: Wenzhou Medical University)
#2Rui Chen (WMC: Wenzhou Medical University)H-Index: 6
Last. He-Lin Xu (WMC: Wenzhou Medical University)H-Index: 20
view all 10 authors...
The self-healing of chemotherapy-induced oral mucositis was difficultly practiced because of both local bacterial infection and severe inflammation. Herein, in situ mucoadhesive hydrogels (PPP_E) was successfully prepared by using temperature-sensitive PLGA-PEG-PLGA (PPP) as matrix and EGCG as adhesion enhancer. Series of PPP_E precursor solution with various EGCG concentration (1%, 2% and 5%) were prepared by fixing the PPP concentration at 25%. EGCG slightly decreased the sol-gel transition te...
#1Qiying Shen (Hangzhou Normal University)H-Index: 4
#2Ting Tang (Hangzhou Normal University)
Last. Yong-Zhong Du (ZJU: Zhejiang University)H-Index: 53
view all 7 authors...
Methotrexate (MTX) as an anti-inflammatory drug for the treatment of rheumatoid arthritis (RA) through oral and injectable administration is still problematic in the clinic. Herein, a MTX-loaded thermal-responsible flexible liposome (MTFL) incorporated within a carbomer-based gel was prepared as a novel transdermal agent (MTFL/Gel) for effective treatment of RA. It was found that MTFL had an average size of approximately 90 nm, which could rapidly release the drug under thermal conditions. The p...
#1Ning Li (SMMU: Second Military Medical University)H-Index: 6
#2Xin Li (SMMU: Second Military Medical University)H-Index: 4
Last. Zhiyun Xu (SMMU: Second Military Medical University)H-Index: 17
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Valvular structural deterioration and calcification are the main indications for secondary intervention after bioprosthetic valve replacement, promoting an urgent requirement for more durable cardiovascular biomaterials for clinical applications. The swim bladder of carp we introduced in this study has several advantages as a raw biomaterial when compared to the bovine pericardium. First, the results of in vitro assays demonstrated that the cross-linked carp swim bladder exhibited superior bioco...
#1Gaole Dai (CUHK: Chinese University of Hong Kong)H-Index: 4
#2Chun Kit K. K. Choi (CUHK: Chinese University of Hong Kong)
Last. Dennis K. P. Ng (CUHK: Chinese University of Hong Kong)H-Index: 66
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A series of glutathione (GSH)-responsive polydopamine (PDA) nanoparticles (NPs) were prepared using a disulfide-linked dopamine dimer as starting material, of which the size could be tuned systematically by adjusting the amount of ammonia solution used. Molecules of a phthalocyanine (Pc)-based photosensitiser and an epidermal growth factor receptor (EGFR)-targeting peptide were then sequentially immobilised on the surface of the NPs through coupling with the surface functionalities of PDA. The i...
#1Chuanliang Cao (NCU: Nanchang University)H-Index: 9
#2Pengren Huang (NCU: Nanchang University)
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3D printed bioactive glass or bioceramic particle reinforced composite scaffolds for bone tissue engineering currently suffer from low particle concentration ( 100% breaking strain) by adding poly(ethylene glycol) which is biocompatible and FDA approved. The scaffolds require no post-printing washing to remove hazardous components. More exposure of HA microparticles on strut surfaces is enabled by incorporating higher HA concentrations. Compared to scaffolds with 72 wt% HA, scaffolds with higher...
#1Michael Chen (TMU: Taipei Medical University)H-Index: 5
#2Ming Thau Sheu (TMU: Taipei Medical University)H-Index: 35
Last. Kuo-Hsiang ChuangH-Index: 9
view all 13 authors...
The therapeutic efficacy of methoxypolyethylene glycol (mPEG)-coated nanomedicines in solid tumor treatment is hindered by tumor-associated fibroblasts (TAFs), which promote tumor progression and form physical barriers. We developed an anti-HER2/anti-FAP/anti-mPEG tri-specific antibody (TsAb) for one-step conversion of mPEG-coated liposomal doxorubicin (Lipo-Dox) to immunoliposomes, which simultaneously target HER2+ breast cancer cells and FAP+ TAFs. The non-covalent modification did not adverse...
#1Miao Feng (Sun Yat-sen University)H-Index: 1
#2Meiting Li (Sun Yat-sen University)
Last. Jie Liu (Sun Yat-sen University)H-Index: 31
view all 8 authors...
Combination therapy has been widely studied for its promising applications in tumor therapy. However, sophisticated nanoplatform and sequential irradiation with different laser sources for phototherapy complicate the treatment process. Unlike integration of therapeutic agents, we reported a FeS2@SRF@BSA nanoplatform for the combination between chemo-combined photothermal therapy (PTT) enhanced photodynamic therapy (PDT) and chemodynamic therapy (CDT) to achieve an “all-in-one” therapeutic agent....
#1Long Zhang (OSU: The Ohio State University)H-Index: 1
#2Nicolas Burns (OSU: The Ohio State University)H-Index: 2
Last. Peixuan Guo (OSU: The Ohio State University)H-Index: 67
view all 5 authors...
Biological nanopores for single-pore sensing have the advantage of size homogeneity, structural reproducibility, and channel amenability. In order to translate this to clinical applications, the functional biological nanopore must be inserted into a stable system for high-throughput analysis. Here we report factors that control the rate of pore insertion into polymer membrane and analyte translocation through the channel of viral DNA packaging motors of Phi29, T3 and T7. The hydrophobicity of am...
#1Gu Wenxiang (Xuzhou Medical College)H-Index: 1
#2Zhiyuan Hua (Xuzhou Medical College)
Last. Chen Hongliang (Xuzhou Medical College)H-Index: 1
view all 9 authors...
Multifunctional phototherapy nanoagents for imaging-guided synergistic photothermal therapy (PTT) and photodynamic therapy (PDT) are highly desirable in the field of solid tumor therapy. Nevertheless, the tumor microenvironment (TME) inherently associated with hypoxia significantly hampers the photodynamic effect of these multifunctional nanoagents. Herein, Pd nanocubes coated with an ultrathin Pt shell were prepared and further conjugated with fluorescein labeled and thiol functionalized polyet...
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