Tongkai Chen
Guangzhou University of Chinese Medicine
PharmacokineticsBiophysicsNanotechnologyBioavailabilityChemistryMaterials scienceIn vitroIn vivoNeuroprotectionZebrafishOral administrationBlood–brain barrierNeurotoxicityParkinson's diseaseDrug deliveryDrugEndocytosisBlack phosphorusCancer therapyDopamineMedicineCell biologyFörster resonance energy transferPharmacology
33Publications
12H-index
395Citations
Publications 32
Newest
#2Zhongjun LiH-Index: 28
Last. Tongkai ChenH-Index: 12
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In recent years, there has been rapid progress in MXene research due to its distinctive two-dimensional structure and outstanding properties. Especially in biomedical applications, MXenes have attracted widespread favor with numerous studies on biosafety, bioimaging, therapy, and biosensing, although their development is still in the experimental stage. A comprehensive understanding of the current status of MXenes in biomedicine will promote their use in clinical applications. Here, we review th...
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#1Tianzhong Li (SZU: Shenzhen University)
#2Yao Liu (Guangzhou University of Chinese Medicine)H-Index: 5
Last. Han Zhang (SZU: Shenzhen University)H-Index: 1
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#1Sha XiongH-Index: 5
#2Jingshan LuoH-Index: 3
Last. Tongkai Chen (Guangzhou University of Chinese Medicine)H-Index: 12
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There has been an exponential increase in the rate of incidence of Parkinson's disease (PD) with aging in the global population. PD, the second most common neurodegenerative disorder, results from damaged dopamine neurons in the substantia nigra pars compacta (SNpc), along with the deposition of abnormal α-synuclein (α-Syn), and the progressive degeneration of neurons in striatal regions. Despite extensive investigations to understand the pathophysiology of PD to develop effective therapies to r...
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#1Yousheng Mo (Guangzhou University of Chinese Medicine)H-Index: 7
#2Lining Duan (Guangzhou University of Chinese Medicine)
Last. Tongkai Chen (Guangzhou University of Chinese Medicine)H-Index: 12
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Intracerebral hemorrhage (ICH) is a neurological disorder resulting from the nontraumatic rupture of blood vessels in the brain. Ferroptosis is a newly identified form of programmed cell death, which is an important pathological feature of ICH injury. At present, the therapeutic efficacy of ICH treatment is far from satisfactory, so it is urgent to develop a safer and more effective method to treat ICH injury. Resveratrol (Res), a widely used nonflavonoid polyphenol compound, plays a neuroprotec...
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#1Yuying Zhao (Guangzhou University of Chinese Medicine)H-Index: 2
#2Sha Xiong (Guangzhou University of Chinese Medicine)H-Index: 5
Last. Tongkai Chen (Guangzhou University of Chinese Medicine)H-Index: 12
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Purpose Ginkgolide B (GB) is a terpene lactone derivative of Ginkgo biloba that is believed to function in a neuroprotective manner ideal for treating Parkinson's disease (PD). Despite its promising therapeutic properties, GB has poor bioavailability following oral administration and cannot readily achieve sufficient exposure in treated patients, limiting its clinical application for the treatment of PD. In an effort to improve its efficacy, we utilized poly(ethylene glycol)-co-poly(e-caprolacto...
1 CitationsSource
#1Guowang Cheng (JUTCM: Jiangxi University of Traditional Chinese Medicine)H-Index: 1
#2Jingshan Luo (Guangzhou University of Chinese Medicine)H-Index: 3
Last. Tongkai Chen (Guangzhou University of Chinese Medicine)H-Index: 12
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Cucucrbituril (CB) belongs to a family of macrocycles that are easily accessible. Their structural specificity provides excellent molecular recognition capabilities, with the ability to be readily ...
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#1Sha Xiong (Guangzhou University of Chinese Medicine)H-Index: 5
#2Zhongjun Li (SZU: Shenzhen University)H-Index: 28
Last. Tongkai Chen (Guangzhou University of Chinese Medicine)H-Index: 12
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The treatment of Parkinson's disease (PD) is hampered by the blood-brain barrier (BBB). As such, there is an urgent need for the development of a novel nanoplatform capable of penetrating the BBB in order to effectively treat PD. In the present study, we utilized black phosphorus nanosheets (BP) containing the brain-targeting ligand lactoferrin (Lf) and loaded with Paeoniflorin (Pae) to obtain Lf-BP-Pae. Through an effective photo-thermal effect, these Lf-BP-Pae particles were capable of travers...
3 CitationsSource
#1Wei Liu (Guangzhou University of Chinese Medicine)H-Index: 8
#1Wei Liu (Guangzhou University of Chinese Medicine)
Last. Tongkai Chen (Guangzhou University of Chinese Medicine)H-Index: 12
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Carbon dots (CDs) exhibit a wide range of desirable properties including excellent photoluminescence, photostability, and water solubility, making them ideally suitable for use in the context of dr...
2 CitationsSource
#1Yao LiuH-Index: 5
#2Dao-Ming ZhuH-Index: 1
Last. Tongkai Chen (Guangzhou University of Chinese Medicine)H-Index: 12
view all 7 authors...
Despite the relative severity of Parkinson’s disease (PD), to date there has been only limited success in preventing or treating this condition owing to the low permeability of the blood-brain barr...
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#1Fong Leong (UM: University of Macau)H-Index: 4
#2Xue Hua (UM: University of Macau)H-Index: 1
Last. Xiaojia Chen (UM: University of Macau)H-Index: 19
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Traditional Chinese medicine (TCM) are becoming more and more popular all over the world. However, quality issues of TCM may lead to medical incidents in practice and therefore quality control is essential to TCM. In this review, the state of TCM in European Pharmacopoeia are compared with that in Chinese Pharmacopoeia, and herbal drugs that are not considered as TCM and not elaborated by TCM working party at European Directorate for the Quality of Medicines & Health Care (EDQM) but present in b...
2 CitationsSource