Grip strength and gait speed as early biomarkers of brain amyloid and tau deposition

Background Screening biomarkers, accessible and measurable at a primary care clinic, may hold the key to risk stratification and prevention efforts in Alzheimer’s and related dementias. Among potential candidates that could fulfill this role, gait speed and grip strength have garnered strong evidence as early predictive factors. The pathophysiologic basis for this association is not clear; it is possible that functional performance is impaired...