Sudha Seshadri
University of Texas at Austin
Genome-wide association studyEpidemiologyFramingham Heart StudyFramingham Risk ScoreInternal medicineHyperintensityCardiologyCohort studyHazard ratioDiseaseDementiaPopulationAlzheimer's diseaseStrokeGeneticsMedicineCohortGerontologyLocus (genetics)Biology
Publications 684
#1A Baril (BU: Boston University)H-Index: 1
#2Alexa Beiser (BU: Boston University)H-Index: 94
Last. Jayandra J. Himali (University of Texas Health Science Center at San Antonio)
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Objective: To test the hypothesis that reduced slow-wave sleep, or N3 sleep, which is thought to underlie the restorative functions of sleep, is associated with MRI markers of brain aging, we evaluated this relationship in the community-based Framingham Heart Study Offspring cohort using polysomnography and brain MRI. Methods: We studied 492 participants (58.8 ± 8.8 years, 49.4% male) free of neurological diseases who completed a brain MRI scan and in-home overnight polysomnography to assess slo...
#1Maria Stefanidou (BU: Boston University)H-Index: 12
#2Alexa Beiser (BU: Boston University)H-Index: 94
Last. Daniel FriedmanH-Index: 36
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Objective To assess the risk of incident epilepsy among participants with prevalent dementia and the risk of incident dementia among participants with prevalent epilepsy in the Framingham Heart Study (FHS). Methods We analyzed prospectively collected data in the Original and Offspring FHS cohorts. To determine the risk of developing epilepsy among participants with dementia and the risk of developing dementia among participants with epilepsy, we used separate, nested, case–control designs and ma...
2 CitationsSource
#2Hideaki Suzuki (Imperial College London)H-Index: 10
Last. Stéphanie Debette (University of Bordeaux)H-Index: 51
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White matter hyperintensities (WMH) are the most common brain-imaging feature of cerebral small vessel disease (SVD), hypertension being the main known risk factor. Here, we identify 27 genome-wide loci for WMH-volume in a cohort of 50,970 older individuals, accounting for modification/confounding by hypertension. Aggregated WMH risk variants were associated with altered white matter integrity (p = 2.5×10-7) in brain images from 1,738 young healthy adults, providing insight into the lifetime imp...
#1Adam C. Naj (UPenn: University of Pennsylvania)H-Index: 31
#2Farid Rajabli (UM: University of Miami)H-Index: 3
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#1Gabriel A. de Erausquin (University of Texas at Austin)H-Index: 21
#2Ignacio Brusco (UBA: University of Buenos Aires)
Last. Tarun Dua (WHO: World Health Organization)H-Index: 25
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#1Valentina R. Garbarino (University of Texas Health Science Center at San Antonio)H-Index: 5
#2Sydney Tran (University of Texas Health Science Center at San Antonio)
Last. Miranda E. Orr (Wake Forest University)
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#1Dina Vojinovic (EUR: Erasmus University Rotterdam)H-Index: 9
#2Marita Kalaoja (University of Oulu)H-Index: 1
Last. Cornelia M. van Duijn (University of Oxford)H-Index: 108
view all 26 authors...
#1Jayandra J. HimaliH-Index: 32
#2Alexa Beiser (BU: Boston University)H-Index: 94
Last. Matthew P. Pase (Harvard University)H-Index: 28
view all 5 authors...
#1Stephan Seiler (UC Davis: University of California, Davis)H-Index: 20
#2Evan Fletcher (UC Davis: University of California, Davis)H-Index: 31
Last. Charles DeCarli (UC Davis: University of California, Davis)H-Index: 113
view all 8 authors...
#1Emer R. McGrath (Harvard University)H-Index: 10
#2Jayandra J. Himali (BU: Boston University)H-Index: 32
Last. Sudha Seshadri (BU: Boston University)H-Index: 95
view all 11 authors...
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