Plasma YKL40 as a biomarker for brain aging and injury in three community cohorts

Background YKL40 is expressed in reactive astrocytes and microglia and is upregulated in numerous neurological conditions associated with heightened neuroinflammation. We explored the utility of circulating YKL40 as a biomarker of accelerated brain aging and subclinical brain injury. Method YKL40 was measured using the Mesoscale Discovery (MSD) multi‐array assay system from stored plasma in three community‐based cohorts: the Atherosclerosis Risk...