Deficiency of malate-aspartate shuttle component SLC25A12 induces pulmonary metastasis

Background Aspartate biosynthesis and its delivery to the cytosol can be crucial for tumor growth in vivo . However, the impact of intracellular aspartate levels on metastasis has not been studied. We previously described that loss-of-aspartate glutamate carrier 1 (SLC25A12 or AGC1), an important component of the malate-aspartate shuttle, impairs cytosolic aspartate levels, NAD + /NADH ratio, mitochondrial respiration, and tumor growth. Here, we...