Reactivation of dormant tumor cells by modified lipids derived from stress-activated neutrophils

Volume: 12, Issue: 572
Published: Dec 2, 2020
Abstract
Tumor recurrence years after seemingly successful treatment of primary tumors is one of the major causes of mortality in patients with cancer. Reactivation of dormant tumor cells is largely responsible for this phenomenon. Using dormancy models of lung and ovarian cancer, we found a specific mechanism, mediated by stress and neutrophils, that may govern this process. Stress hormones cause rapid release of proinflammatory S100A8/A9 proteins by...
Paper Details
Title
Reactivation of dormant tumor cells by modified lipids derived from stress-activated neutrophils
Published Date
Dec 2, 2020
Volume
12
Issue
572
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