Staphylococcus aureus is a major human pathogen causing serious implant–associated infections. Combination treatment with rifampin (10 to 15 mg/kg per day), which has dose-dependent activity, is re...
Last. Martin S. Davey(Monash University, Clayton campus)H-Index: 17
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Repeated Plasmodium falciparum infections drive the development of clinical immunity to malaria in humans; however, the immunological mechanisms that underpin this response are only partially under...
Last. Michael Gotthardt(Charité - University Medicine Berlin)H-Index: 32
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Heart failure with preserved ejection fraction (HFpEF) is prevalent and deadly, but so far, there is no targeted therapy. A main contributor to the disease is impaired ventricular filling, which we...
Last. Kian-Huat Lim(WUSTL: Washington University in St. Louis)H-Index: 22
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Combination chemotherapies remain the cornerstone treatment for pancreatic ductal adenocarcinoma (PDAC), but de novo and acquired resistance is common. In this study, we aimed to identify and chara...
The hemizygous R47H variant of triggering receptor expressed on myeloid cells 2 (TREM2), a microglia-specific gene in the brain, increases risk for late-onset Alzheimer’s disease (AD). Using transc...
Lysosome dysfunction is a shared feature of rare lysosomal storage diseases and common age-related neurodegenerative diseases. Microglia, the brain-resident macrophages, are particularly vulnerable...
Although mRNA vaccines encoding the spike protein of SARS-CoV-2 prevent COVID-19, the emergence of new viral variants jeopardize their efficacy. Here, we assessed the immunogenicity and protective ...
The macro- and microvascular complications of type 1 and 2 diabetes lead to increased disease severity and mortality. The receptor for advanced glycation end products (RAGE) can bind AGEs and multi...
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