Efficient DNA Walker Guided with Well-Regulated Interfacial Tracks for Ultrasensitive Electrochemiluminescence Biosensing

Herein, highly efficient deoxyribonucleic acid (DNA) walking on electrode surfaces was realized by regulating DNA tracks, which was applied to construct an ultrasensitive electrochemiluminescent (ECL) biosensor for BCR/ABL fusion gene detection. The well-regulated DNA tracks were constructed via supersandwich hybridization chain reaction of two DNA strands (L1 and L2) to generate periodic linear dsDNA concatemers, where an exposed L1 domain...