Analytical Chemistry
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#1Marko Pavlovic (University of Novi Sad)H-Index: 2
#2Heman Kumar Ramiya Ramesh Babu (University of Novi Sad)
Last. Lukas Zeininger (MPG: Max Planck Society)H-Index: 10
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The cationic content of water represents a major quality control parameter that needs to be followed by a rapid, on-site, and low-cost method. Herein, we report a novel method for a facile monitoring of the mineral content of drinking water by making use of responsive complex emulsions. The morphology of biphasic oil-in-water droplets solely depends on the balance of interfacial tensions, and we demonstrate that changes in the surfactant effectiveness, caused by variations in the mineral content...
#1Jun-Tao Cao (Xinyang Normal University)H-Index: 22
#2Jing-Lu Lv (Xinyang Normal University)H-Index: 2
Last. Yan-Ming Liu (Xinyang Normal University)H-Index: 34
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To achieve high sensitivity for biomolecule detection in photoelectrochemical (PEC) bioanalysis, the ideal photoelectrode and ingenious signaling mechanism play crucial roles. Herein, the feasibility of the photogenerated hole-induced chemical-chemical redox cycling amplification strategy on a Z-scheme heterostructure photoelectrode was validated, and the strategy toward enhanced multiple signal amplification for advanced PEC immunoassay application was developed. Specifically, a direct Z-scheme...
#1Zhuo Zou (Suzhou University of Science and Technology)H-Index: 1
#2Zhuan Zhuan Shi (Suzhou University of Science and Technology)
Last. Hong Chen (SWU: Southwest University)
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Single-atom catalysis efficiently exposes the catalytic sites to reactant molecules while rendering opportunity to investigate the catalysis mechanisms at atomic levels for scientific insights. Here, for the first time, atomically dispersed Co atoms are synthesized as biomimetic "enzymes" to monitor superoxide anions (O2•-), delivering ultraordinary high sensitivity (710.03 μA·μM-1·cm-2), low detection limit (1.5 nM), and rapid response time (1.2 s), ranking the best among all the reported eithe...
#1Sibylle Pfammatter (UdeM: Université de Montréal)H-Index: 6
#2Zhaoguan Wu (UdeM: Université de Montréal)
Last. Jean-Jacques Dunyach (Thermo Fisher Scientific)H-Index: 8
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High-field asymmetric waveform ion mobility spectrometry (FAIMS) has gained popularity in the proteomics field for its capability to improve mass spectrometry sensitivity and to decrease peptide co-fragmentation. The recent implementation of FAIMS on Tribrid Orbitrap instruments enhanced proteome coverage and increased the precision of quantitative measurements. However, the FAIMS interface has not been available on older generation Orbitrap mass spectrometers such as the Q-Exactive. Here, we re...
#1Alessandra Zanut (UNIBO: University of Bologna)H-Index: 8
#2Marianna Rossetti (University of Rome Tor Vergata)H-Index: 5
Last. Giovanni Valenti (UNIBO: University of Bologna)H-Index: 70
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Electrochemiluminescence (ECL) is a powerful transduction technique that has rapidly gained importance as a powerful analytical technique. Since ECL is a surface-confined process, a comprehensive understanding of the generation of ECL signal at a nanometric distance from the electrode could lead to several highly promising applications. In this work, we explored the mechanism underlying ECL signal generation on the nanoscale using luminophore-reporter-modified DNA-based nanoswitches (i.e., molec...
#1Hansen Zhao (THU: Tsinghua University)H-Index: 6
#2Feng Ge (THU: Tsinghua University)H-Index: 1
Last. Yan He (THU: Tsinghua University)H-Index: 18
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Understanding the spatiotemporal dynamics of particles in a complex biological environment is crucial for the study of related biological processes. To analyze the complicated trajectories recorded from single-particle tracking (SPT), we have proposed a method named SEES based on historical experience vector analysis, which allows both the global patterns and local state continuities of a trajectory to emerge by themselves as color segments without predefined models. This method implements a dat...
#1Xinyang Zhu (CAS: Chinese Academy of Sciences)H-Index: 2
#2Huanhuan Xing (CAS: Chinese Academy of Sciences)H-Index: 10
Last. Shaojun Dong (USTC: University of Science and Technology of China)H-Index: 131
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A chemical fixation strategy originating from single-atom-anchoring with metal-organic frameworks as a carrying matrix was proposed for solid-state electrochemiluminescence (ECL). Herein, UiO-67(N) with the exposure of 2,2'-bipyridine (bpy) ligands could coordinate with Ru2+ to form a local structure of [Ru(bpy)3]2+ (Ru-UiO). The influence of the steric effect induced with different Ru sources was discussed. The as-obtained Ru-UiO exhibits high ECL intensity and outstanding stability in the pres...
#1Xiaolong Zhang (SWU: Southwest University)H-Index: 3
#2Yu-Han Liu (SWU: Southwest University)
Last. Ruo Yuan (SWU: Southwest University)H-Index: 84
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In this work, an original rolling-circle strand displacement amplification (RC-SDA) was developed by introducing a circle DNA with two recognition domains as a template instead of the limited liner DNA template in traditional strand displacement amplification (SDA), which displayed much shorter reaction time down to 30 min and quite higher conversion efficiency of more than 1.77 × 108 compared with those of traditional strand displacement amplification (SDA) and could be applied to construct a l...
#1Xiangkun Yang (Regeneron)
#2Haeri Seol (Regeneron)
Last. Ning Li (Regeneron)H-Index: 6
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Antibody-drug conjugates (ADCs) are biopharmaceuticals for the targeted delivery of antitumor agents. ADCs can be highly heterogeneous with various drug-to-antibody ratio (DAR) species, conjugation sites, and occupancy levels. The conjugation site can modulate the ADC stability and efficacy and therefore can be considered to be a critical quality attribute (CQA) during development. Traditional mass spectrometry (MS)-based peptide mapping methods cannot accurately quantify site-specific conjugati...
#1Pierre Millard (University of Toulouse)H-Index: 14
#2Serguei Sokol (University of Toulouse)H-Index: 11
Last. Jean-Charles PortaisH-Index: 38
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Stable-isotope labeling experiments are widely used to investigate the topology and functioning of metabolic networks. Label incorporation into metabolites can be quantified using a broad range of mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy methods, but in general, no single approach can completely cover isotopic space, even for small metabolites. The number of quantifiable isotopic species could be increased and the coverage of isotopic space improved by integrating...
Top fields of study
Analytical chemistry
Mass spectrometry
Inorganic chemistry